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Table 2 Baseline characteristics, interventions used and glucometrics of patients reaching an average glycemia ≤110 mg/dl versus those with an average glycemia >110 mg/dl

From: A comparison of two insulin infusion protocols in the medical intensive care unit by continuous glucose monitoring

  Avg glyc ≤ 110 mg/dl Avg glyc >110 mg/dl Statistics
Number of patients 19 38  
Patient demographics    
 Men/women 8/11 22/16 NS
 Diabetic status (no/type1/type2) 14/1/4 23/4/11 NS
 Age (years) 65 ± 11 63 ± 12 NS
 BMI (kg/m2) 26.3 ± 3.8 27.1 ± 6.1 NS
Severity of illness    
 APACHE-II score 27 ± 6 28 ± 7 NS
 SOFA score 10 ± 4 10 ± 3 NS
Clinical interventions    
 Mechanical ventilation 14 31 NS
 Vasopressor therapy 12 23 NS
 Hemodialysis 5 9 NS
 No/total parenteral/enteral feeding 4/6/9 13/11/14 NS
 Glucocorticoids 15 12 0.01
 Antibiotics 17 29 NS
Protocol (Leuven/Yale) 7/12 15/23 NS
Insulin dose    
 Day 1 (units) 62 (33–133) 63 (39–128) NS
 Day 2 (units) 67 (23–101) 70 (42–120) NS
Glucose parameters    
 HbA1c (%) 6.1 (5.6–6.7) 6.0 (5.8–6.9) NS
 HbA1c (mmol/mol) 43 (38–50) 70 (42–120) NS
 Median glycemia (mg/dl) 104 (100–108) 128 (119–141) <0.0001
 % of time at glycemia    
  <60 mg/dl 5 (0–8) 0 (0–4) 0.067
  80–110 mg/dl 41 ± 14 27 ± 13 0.001
  >150 mg/dl 6 ± 6 28 ± 18 <0.0001
  >200 mg/dl 1 ± 2 10 ± 16 0.017
  60–150 mg/dl 89 ± 11 69 ± 19 <0.0001
  70–180 mg/dl 86 ± 14 80 ± 19 NS
 Nr of art blood glc measurements/day 10 ± 3 10 ± 4 NS
 Glucose variability parameters    
  SD (mg/dl) 25 (20–36) 38 (29–63) 0.003
  Coefficient of variation (%) 25 (20–33) 29 (23–44) NS
  IQR 33 (27–55) 45 (35–76) 0.031
  MAGE (mg/dl) 50 (34–72) 60 (43–100) 0.085
  MODD (mg/dl) 29 (22–45) 42 (32–76) 0.005
  M-100 2 (1–4) 6 (4–14) 0.001
  CONGA1 (mg/dl) 15 (12–19) 21 (15–35) 0.008
  CONGA2 (mg/dl) 22 (17–28) 32 (20–48) 0.010
  CONGA4 (mg/dl) 29 (18–43) 42 (27–69) 0.011
  LBGI 2.7 (0.9–3.8) 0.7 (0.2–1.9) 0.001
  HBGI 0.3 (0.2–1.1) 2.0 (1.4–4.5) <0.0001
  Glucose variability 21 (17–28) 36 (29–53) <0.0001
  1. Data are presented as numbers, as mean ± SD or median (25–75th percentile)
  2. LOS in ICU length of stay in ICU, IQR interquartile range, MAGE mean amplitude of glycemic excursions, MODD mean of daily differences, LBGI low blood glucose index, HBGI high BGI