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Table 3 Baseline characteristics, interventions used and glucometrics of non-diabetic versus diabetic patients

From: A comparison of two insulin infusion protocols in the medical intensive care unit by continuous glucose monitoring

  Non-DM DM Statistics
Number of patients 36 21  
Patient demographics    
 Men/women 19/17 11/10 NS
 Age (years) 65 ± 11 62 ± 12 NS
 BMI (kg/m2) 26 ± 4 29 ± 7 0.02
Severity of illness    
 APACHE-II score 29 ± 6 26 ± 7 NS
 SOFA score 11 ± 4 9 ± 3 NS (0.064)
Clinical interventions    
 Mechanical ventilation 27 17 NS
 Vasopressor therapy 23 12 NS
 Hemodialysis 12 2 NS (0.06)
 No/total parenteral/enteral feeding 7/13/16 10/4/7 NS (0.075)
 Glucocorticoids 20 7 NS
 Antibiotics 30 16 NS
Protocol (Leuven/Yale) 9/27 13/8 0.009
Insulin dose    
 Day 1 (units) 48 (26–82) 127 (51–175) 0.001
 Day 2 (units) 46 (25–85) 113 (67–168) 0.009
Glucose parameters    
 HbA1c (%) 5.9 (5.6–6.3) 6.9 (6.1–7.3) <0.0001
 HbA1c (mmol/mol) 41 (38–45) 52 (43–56) <0.0001
 Median glycemia (mg/dl) 116 (107–128) 131 (110–166) 0.034
 % of time at glycemia    
  <60 mg/dl 0 (0–1) 4 (1–10) 0.001
  80–110 mg/dl 36 ± 15 25 ± 12 0.006
  >150 mg/dl 32 ± 15 24 ± 11 0.001
  >200 mg/dl 3 ± 15 15 ± 20 0.001
  60–150 mg/dl 83 ± 12 63 ± 23 <0.0001
  70–180 mg/dl 90 ± 11 69 ± 19 <0.0001
 Nr of art blood glc measurements/day 10 ± 4 10 ± 3 NS
 Glucose variability parameters    
  SD (mg/dl) 28 (21–35) 53 (40–75) <0.0001
  Coefficient of variation (%) 23 (19–30) 38 (29–51) <0.0001
  IQR 38 (28–45) 66 (41–108) <0.0001
  MAGE (mg/dl) 49 (35–66) 87 (56–127) 0.002
  MODD (mg/dl) 35 (26–42) 59 (35–116) <0.0001
  M-100 4 (2–5) 12 (6–29) <0.0001
  CONGA1 (mg/dl) 15 (13–20) 30 (19–41) <0.0001
  CONGA2 (mg/dl) 22 (17–30) 44 (26–59) <0.0001
  CONGA4 (mg/dl) 30 (21–43) 60 (37–86) <0.0001
  LBGI 0.7 (0.3–1.8) 2.3 (0.9–3.7) 0.013
  HBGI 1.2 (0.4–1.8) 3.0 (1.4–10.3) 0.002
  Glucose variability 28 (20–34) 44 (34–79) <0.0001
  1. Data are presented as numbers, as mean ± SD or median (25–75th percentile)
  2. LOS in ICU length of stay in ICU, IQR interquartile range, MAGE mean amplitude of glycemic excursions, MODD mean of daily differences, LBGI low blood glucose index, HBGI high BGI