Three-year mortality in 30-day survivors of critical care with acute kidney injury: data from the prospective observational FINNAKI study

Annals of Intensive Care

Table 2 Multivariable adjusted Cox proportional hazards model for time to death during the 3-year follow-up

Characteristic	Hazard ratio (95% CI)	p value
Age (years)	1.03 (1.03–1.04)	<0.001
Gender (female)	0.82 (0.68–0.98)	0.047
Functional performance^a (normal as the reference)
Disabled to work but no need for assistance	1.65 (1.32–2.08)	<0.001
Some assistance required	2.65 (2.00–3.54)	<0.001
Totally dependent on assistance	3.48 (2.32–5.22)	<0.001
Comorbidities^b
Arteriosclerosis	1.05 (0.81–1.37	0.703
Chronic kidney disease	1.53 (1.23–2.07)	0.006
Chronic obstructive pulmonary disease	1.63 (1.26–2.10)	<0.001
Diabetes mellitus	1.15 (0.92–1.43)	0.219
Hypertension	0.85 (0.69–1.04)	0.125
Chronic liver failure	2.90 (1.89–4.44)	<0.001
Malignancy	3.18 (2.18–4.62)	<0.001
Rheumatoid disease	1.87 (1.35–2.60)	<0.001
Systolic heart failure	0.96 (0.73–1.26)	0.774
Thrombophilia	0.83 (0.57–1.20)	0.313
Operative admission	1.04 (0.84–1.30)	0.710
Emergency admission	1.65 (1.16–2.33)	0.005
SAPS without age and renal points (per point)^c	1.00 (0.99–1.01)	0.646
Vasoactive drugs	1.12 (0.90–1.39)	0.296
Severe sepsis	1.09 (0.89–1.33)	0.422
Acute kidney injury	1.05 (0.86–1.27)	0.644

Model included 2305 patients and met the assumption of constant proportional hazards
Non-op non-operative, post-op postoperative, SAPS Simplified Acute Physiology Score
^aData from five patients were missing and assumed to be normal
^bPatients with missing data were assumed not to have the chronic condition. Number of patients with imputed data according to comorbidity: arteriosclerosis 24, chronic kidney disease 9, chronic obstructive pulmonary disease 14, diabetes 4, hypertension 14, liver failure 24, malignancy 136, rheumatoid disease 18, systolic heart failure 21, and thrombophilia 11
^cData missing from 31 patients