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Table 1 Multivariate Cox proportional hazard regression analysis on treatment effects among medical patients (a) and non-medical patients (b)

From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

Parameter

Parameter estimate

Standard error

Hazard ratio

95% CI of the hazard ratio

P value

1a: Medical patients (n = 109)

IMHP versus HP

0.922

0.319

2.515

[1.360, 4.783]

0.004

Age group 1 versus 4

−2.651

0.788

0.071

[0.011, 0.275]

<0.001

Age group 2 versus 4

−1.439

0.393

0.237

[0.110, 0.522]

<0.001

Age group 3 versus 4

−1.120

0.409

0.326

[0.145, 0.733]

0.006

APACHE-II score

0.017

0.019

1.017

[0.980, 1.057]

0.376

2a: Non-medical patients (n = 192)

IMHP versus HP

−0.034

0.296

0.967

[0.540, 1.736]

0.909

Age group 1 versus 4

−1.595

0.533

0.203

[0.068, 0.562]

0.003

Age group 2 versus 4

−1.489

0.434

0.226

[0.095, 0.531]

<0.001

Age group 3 versus 4

−0.467

0.381

0.627

[0.299, 1.353]

0.219

APACHE-II score

0.101

0.026

1.106

[1.052, 1.165]

<0.001

  1. IMHP immune-modulating high-protein enteral nutrition, HP high-protein enteral nutrition, age group 1 age ≤50 year, age group 2 age 51–70 years, age group 3 age 71–80 years, age group 4 age >80 years, APACHE-II acute physiology and chronic health evaluation-II