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Table 2 Associations of baseline plasma concentrations of immune-modulating ingredients and 6-month mortality in all, medical and non-medical critically ill patients

From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

Immunonutrient (unit) Univariate analysis Multivariate analysis
Coef. SE Hazard ratio 95% CI of the hazard ratio P value Coef. SE Hazard ratio 95% CI of the hazard ratio P value
2a: All patients (n = 301)
Glutamine (μmol/L) 0.00119 0.00059 1.001 [1.000, 1.002] 0.046 0.00034 0.00065 1.000 [0.999, 1.001] 0.599
(epa + dha)/lcf ratio (×10−2) 0.21174 0.09876 1.236 [1.012, 1.491] 0.032 −0.02082 0.10415 0.979 [0.794, 1.195] 0.842
Selenium (μmol/L) 0.06623 0.16564 1.068 [0.737, 1.416] 0.689 0.11961 0.14465 1.127 [0.814, 1.448] 0.408
Vit E (μmol/L) −0.00416 0.01402 0.996 [0.968, 1.023] 0.766 −0.00750 0.01458 0.993 [0.964, 1.021] 0.607
Vit C (μmol/L) 0.00297 0.00754 1.003 [0.986, 1.015] 0.694 −0.00507 0.00817 0.995 [0.977, 1.009] 0.535
Zinc (μmol/L) 0.01189 0.02532 1.012 [0.961, 1.061] 0.639 0.02327 0.02437 1.024 [0.974, 1.071] 0.340
2b: Medical patients (n = 109)
Glutamine (μmol/L) −0.00011 0.00090 1.000 [0.998, 1.002] 0.901 −0.00025 0.00095 1.000 [0.998, 1.002] 0.792
(epa + dha)/lcf ratio (×10−2) 0.16155 0.12798 1.175 [0.905, 1.496] 0.207 −0.04175 0.13716 0.959 [0.727, 1.246] 0.761
Selenium (μmol/L) 0.06647 0.17729 1.069 [0.689, 1.420] 0.708 0.06778 0.18363 1.070 [0.685, 1.457] 0.712
Vit E (μmol/L) −0.00370 0.01981 0.996 [0.957, 1.035] 0.852 −0.00299 0.02107 0.997 [0.955, 1.038] 0.887
Vit C (μmol/L) −0.00611 0.00966 0.994 [0.972, 1.009] 0.527 −0.00773 0.00995 0.992 [0.970, 1.008] 0.437
Zinc (μmol/L) 0.04600 0.02592 1.047 [0.992, 1.098] 0.076 0.06078 0.02729 1.063 [1.004, 1.118] 0.026
2c: Non-medical patients
Glutamine (μmol/L) 0.00169 0.00074 1.002 [1.000, 1.003] 0.023 0.00067 0.00076 1.001 [0.999, 1.002] 0.377
(epa + dha)/lcf ratio (×10−2) 0.29408 0.14469 1.342 [0.996, 1.757] 0.042 0.03667 0.16425 1.037 [0.740, 1.410] 0.823
Selenium (μmol/L) 0.06196 0.29028 1.064 [0.570, 1.785] 0.831 0.11013 0.27021 1.116 [0.625, 1.816] 0.684
Vit E (μmol/L) −0.01053 0.02043 0.990 [0.948, 1.027] 0.606 −0.01162 0.02052 0.988 [0.949, 1.028] 0.571
Vit C (μmol/L) 0.02023 0.01849 1.020 [0.982, 1.056] 0.274 0.01667 0.01899 1.017 [0.978, 1.054] 0.380
Zinc (μmol/L) −0.10003 0.04612 0.905 [0.824, 0.988] 0.030 −0.06168 0.04475 0.940 [0.857, 1.022] 0.168
  1. The multivariate statistical model includes the variables “age group” and “Apache-II score” as covariates. Coef = coefficient. The coefficient is the Cox proportional hazard regression parameter estimate; a positive coefficient indicates a worse prognosis, and a negative coefficient indicates a protective effect of the variable on 6-month mortality. Coefficient values represent changes per unit of nutrient for the different immunonutrients and change per percentage for (epa + dha)/lcf ratio. SE is the parameter estimate standard regression. P values represent Chi-square statistic testing the null hypothesis that the estimate is zero