From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis
Immunonutrient (unit) | Univariate analysis | Multivariate analysis | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Coef. | SE | Hazard ratio | 95% CI of the hazard ratio | P value | Coef. | SE | Hazard ratio | 95% CI of the hazard ratio | P value | |
2a: All patients (n = 301) | ||||||||||
Glutamine (μmol/L) | 0.00119 | 0.00059 | 1.001 | [1.000, 1.002] | 0.046 | 0.00034 | 0.00065 | 1.000 | [0.999, 1.001] | 0.599 |
(epa + dha)/lcf ratio (×10−2) | 0.21174 | 0.09876 | 1.236 | [1.012, 1.491] | 0.032 | −0.02082 | 0.10415 | 0.979 | [0.794, 1.195] | 0.842 |
Selenium (μmol/L) | 0.06623 | 0.16564 | 1.068 | [0.737, 1.416] | 0.689 | 0.11961 | 0.14465 | 1.127 | [0.814, 1.448] | 0.408 |
Vit E (μmol/L) | −0.00416 | 0.01402 | 0.996 | [0.968, 1.023] | 0.766 | −0.00750 | 0.01458 | 0.993 | [0.964, 1.021] | 0.607 |
Vit C (μmol/L) | 0.00297 | 0.00754 | 1.003 | [0.986, 1.015] | 0.694 | −0.00507 | 0.00817 | 0.995 | [0.977, 1.009] | 0.535 |
Zinc (μmol/L) | 0.01189 | 0.02532 | 1.012 | [0.961, 1.061] | 0.639 | 0.02327 | 0.02437 | 1.024 | [0.974, 1.071] | 0.340 |
2b: Medical patients (n = 109) | ||||||||||
Glutamine (μmol/L) | −0.00011 | 0.00090 | 1.000 | [0.998, 1.002] | 0.901 | −0.00025 | 0.00095 | 1.000 | [0.998, 1.002] | 0.792 |
(epa + dha)/lcf ratio (×10−2) | 0.16155 | 0.12798 | 1.175 | [0.905, 1.496] | 0.207 | −0.04175 | 0.13716 | 0.959 | [0.727, 1.246] | 0.761 |
Selenium (μmol/L) | 0.06647 | 0.17729 | 1.069 | [0.689, 1.420] | 0.708 | 0.06778 | 0.18363 | 1.070 | [0.685, 1.457] | 0.712 |
Vit E (μmol/L) | −0.00370 | 0.01981 | 0.996 | [0.957, 1.035] | 0.852 | −0.00299 | 0.02107 | 0.997 | [0.955, 1.038] | 0.887 |
Vit C (μmol/L) | −0.00611 | 0.00966 | 0.994 | [0.972, 1.009] | 0.527 | −0.00773 | 0.00995 | 0.992 | [0.970, 1.008] | 0.437 |
Zinc (μmol/L) | 0.04600 | 0.02592 | 1.047 | [0.992, 1.098] | 0.076 | 0.06078 | 0.02729 | 1.063 | [1.004, 1.118] | 0.026 |
2c: Non-medical patients | ||||||||||
Glutamine (μmol/L) | 0.00169 | 0.00074 | 1.002 | [1.000, 1.003] | 0.023 | 0.00067 | 0.00076 | 1.001 | [0.999, 1.002] | 0.377 |
(epa + dha)/lcf ratio (×10−2) | 0.29408 | 0.14469 | 1.342 | [0.996, 1.757] | 0.042 | 0.03667 | 0.16425 | 1.037 | [0.740, 1.410] | 0.823 |
Selenium (μmol/L) | 0.06196 | 0.29028 | 1.064 | [0.570, 1.785] | 0.831 | 0.11013 | 0.27021 | 1.116 | [0.625, 1.816] | 0.684 |
Vit E (μmol/L) | −0.01053 | 0.02043 | 0.990 | [0.948, 1.027] | 0.606 | −0.01162 | 0.02052 | 0.988 | [0.949, 1.028] | 0.571 |
Vit C (μmol/L) | 0.02023 | 0.01849 | 1.020 | [0.982, 1.056] | 0.274 | 0.01667 | 0.01899 | 1.017 | [0.978, 1.054] | 0.380 |
Zinc (μmol/L) | −0.10003 | 0.04612 | 0.905 | [0.824, 0.988] | 0.030 | −0.06168 | 0.04475 | 0.940 | [0.857, 1.022] | 0.168 |