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Table 5 Associations between changes in (epa + dha)/lcf ratio from baseline to day 4 and 6-month mortality in medical critically ill patients

From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

(epa + dha)/lcf ratio parameters

6-months mortality

 

Cox proportional hazard model analysis

Incidence (%)

 

Coef.

SE

Hazard ratio

95% CI of the hazard ratio

P value

(epa + dha)/lcf ratio (×10−2), continuous

  

0.162

0.070

1.176

[1.023, 1.348]

0.021

(epa + dha)/lcf ratio (×10−2), recoded to quartiles

       

 Q1 cutpoint: <−0.44

33

Q1 versus Q4

−0.667

0.486

0.513

[0.191, 1.324]

0.170

 Q2 cutpoints: ≥−0.44 to <0.11

35

Q2 versus Q4

−0.960

0.506

0.383

[0.137, 1.023]

0.058

 Q3 cutpoints: ≥0.11 to <3.19

48

Q3 versus Q4

0.076

0.447

1.079

[0.447, 2.627]

0.865

 Q4 cutpoint: ≥3.19

46

      
  

Overall

    

0.105

(epa + dha)/lcf ratio (×10−2), recoded to ≥0 versus <0

       

 <0

34

≥ 0 versus <0

1.030

0.383

2.800

[1.344, 6.098]

0.007

 ≥0

46

      
  1. Coef coefficient. The coefficient is the Cox proportional hazard regression parameter estimate; a positive coefficient indicates a worse prognosis, and a negative coefficient indicates a protective effect of the variable on 6-month mortality. Coefficient values represent changes per percentage for (epa + dha)/lcf ratio. SE is the parameter estimate standard regression. P values represent Chi-square statistic testing the null hypothesis that the estimate is zero