Skip to main content

Table 5 Associations between changes in (epa + dha)/lcf ratio from baseline to day 4 and 6-month mortality in medical critically ill patients

From: Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis

(epa + dha)/lcf ratio parameters 6-months mortality   Cox proportional hazard model analysis
Incidence (%)   Coef. SE Hazard ratio 95% CI of the hazard ratio P value
(epa + dha)/lcf ratio (×10−2), continuous    0.162 0.070 1.176 [1.023, 1.348] 0.021
(epa + dha)/lcf ratio (×10−2), recoded to quartiles        
 Q1 cutpoint: <−0.44 33 Q1 versus Q4 −0.667 0.486 0.513 [0.191, 1.324] 0.170
 Q2 cutpoints: ≥−0.44 to <0.11 35 Q2 versus Q4 −0.960 0.506 0.383 [0.137, 1.023] 0.058
 Q3 cutpoints: ≥0.11 to <3.19 48 Q3 versus Q4 0.076 0.447 1.079 [0.447, 2.627] 0.865
 Q4 cutpoint: ≥3.19 46       
   Overall      0.105
(epa + dha)/lcf ratio (×10−2), recoded to ≥0 versus <0        
 <0 34 ≥ 0 versus <0 1.030 0.383 2.800 [1.344, 6.098] 0.007
 ≥0 46       
  1. Coef coefficient. The coefficient is the Cox proportional hazard regression parameter estimate; a positive coefficient indicates a worse prognosis, and a negative coefficient indicates a protective effect of the variable on 6-month mortality. Coefficient values represent changes per percentage for (epa + dha)/lcf ratio. SE is the parameter estimate standard regression. P values represent Chi-square statistic testing the null hypothesis that the estimate is zero