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Table 1 Characteristics of patients in the sepsis cohort

From: Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients

  Total (n = 2534) ARDS (n = 156) No ARDS (n = 2378) p value
APACHE II 11.7 ± 6.4 16.3 ± 7.4 11.4 ± 6.2 <0.001
Age (years) 58.5 ± 18.8 54.9 ± 17.3 58.8 ± 18.9 0.01
Total fluid infused during first 6 h (L) 1.49 ± 1.51 2.54 ± 2.31 1.41 ± 1.42 <0.001
Race     0.04
 White 1448 (59.2) 97 (63.8) 1351 (58.9)  
 Black 724 (29.6) 31 (20.4) 693 (30.2)  
 Asian 35 (1.4) 3 (2.0) 32 (1.4)  
 Other 240 (9.8) 21 (13.8) 219 (9.5)  
Shock 234 (9.23) 44 (28.2) 190 (8.0) <0.001
Male 1298 (51.2) 94 (60.3) 1204 (50.6) 0.02
Pneumonia as site of infection 1234 (48.7) 91 (58.33) 1143 (48.1) 0.01
Alcohol use 596 (26.0) 41 (29.3) 555 (25.8) 0.36
Blood product transfusion 51 (2.6) 10 (8.6) 41 (2.2) <0.001
Aspiration 103 (4.1) 15 (9.6) 88 (3.7) <0.001
Pancreatitis 24 (1.0) 5 (3.2) 19 (0.8) 0.003
Thoracic surgery 6 (0.2) 0 (0.0) 6 (0.3) 0.53
Spine surgery 3 (0.1) 2 (1.3) 1 (0.0) <0.001
Acute abdomen 42 (1.7) 6 (3.9) 36 (1.5) 0.03
Cardiac surgery 3 (0.1) 0 (0.0) 3 (0.1) 0.66
Aortic surgery 3 (0.1) 0 (0.0) 3 (0.1) 0.66
Lung contusion 2 (0.1) 0 (0.0) 2 (0.1) 0.72
Near drowning 0 (0) 0 0 NA
Brain injury 11 (0.4) 3 (1.9) 8 (0.34) 0.004
Smoke inhalation 4 (0.2) 1 (0.6) 3 (0.1) 0.12
Long-bone fractures 5 (0.2) 3 (1.9) 2 (0.1) <0.001
Obesity (BMI > 30) 598 (23.6) 44 (28.2) 554 (23.3) 0.16
Chemotherapy 131 (5.2) 10 (6.4) 121 (5.1) 0.47
Diabetes mellitus 733 (28.9) 33 (21.1) 700 (29.4) 0.03
Tobacco use     0.83
 Never 1177 (49.7) 73 (51.4) 1104 (49.6)  
 Former 652 (27.6) 36 (25.4) 616 (27.7)  
 Current 538 (22.7) 33 (23.3) 505 (22.7)  
Emergency surgery 41 (1.6) 5 (3.2) 36 (1.5) 0.10
Tachypnea (RR > 30) 239 (9.7) 30 (20.0) 209 (9.0) <0.001
Hypoxemia (SpO2 < 95%) 861 (34.6) 68 (44.2) 793 (34.0) 0.01
FIO2 >0.35 395 (17.0) 61 (41.2) 334 (15.4) <0.001
Hypoalbuminemia 695 (54.9) 64 (74.4) 631 (53.4) <0.001
Acidosis (pH < 7.35) 231 (42.5) 50 (55.6) 181 (40.0) 0.006
  1. Data are presented as mean ± SD or n (%) unless otherwise indicated
  2. APACHE Acute Physiology and Chronic Health Evaluation, BMI body mass index, RR respiratory rate