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Table 1 Characteristics of patients in the sepsis cohort
| Total (n = 2534) | ARDS (n = 156) | No ARDS (n = 2378) | p value | |
|---|---|---|---|---|
| APACHE II | 11.7 ± 6.4 | 16.3 ± 7.4 | 11.4 ± 6.2 | <0.001 |
| Age (years) | 58.5 ± 18.8 | 54.9 ± 17.3 | 58.8 ± 18.9 | 0.01 |
| Total fluid infused during first 6 h (L) | 1.49 ± 1.51 | 2.54 ± 2.31 | 1.41 ± 1.42 | <0.001 |
| Race | 0.04 | |||
| White | 1448 (59.2) | 97 (63.8) | 1351 (58.9) | |
| Black | 724 (29.6) | 31 (20.4) | 693 (30.2) | |
| Asian | 35 (1.4) | 3 (2.0) | 32 (1.4) | |
| Other | 240 (9.8) | 21 (13.8) | 219 (9.5) | |
| Shock | 234 (9.23) | 44 (28.2) | 190 (8.0) | <0.001 |
| Male | 1298 (51.2) | 94 (60.3) | 1204 (50.6) | 0.02 |
| Pneumonia as site of infection | 1234 (48.7) | 91 (58.33) | 1143 (48.1) | 0.01 |
| Alcohol use | 596 (26.0) | 41 (29.3) | 555 (25.8) | 0.36 |
| Blood product transfusion | 51 (2.6) | 10 (8.6) | 41 (2.2) | <0.001 |
| Aspiration | 103 (4.1) | 15 (9.6) | 88 (3.7) | <0.001 |
| Pancreatitis | 24 (1.0) | 5 (3.2) | 19 (0.8) | 0.003 |
| Thoracic surgery | 6 (0.2) | 0 (0.0) | 6 (0.3) | 0.53 |
| Spine surgery | 3 (0.1) | 2 (1.3) | 1 (0.0) | <0.001 |
| Acute abdomen | 42 (1.7) | 6 (3.9) | 36 (1.5) | 0.03 |
| Cardiac surgery | 3 (0.1) | 0 (0.0) | 3 (0.1) | 0.66 |
| Aortic surgery | 3 (0.1) | 0 (0.0) | 3 (0.1) | 0.66 |
| Lung contusion | 2 (0.1) | 0 (0.0) | 2 (0.1) | 0.72 |
| Near drowning | 0 (0) | 0 | 0 | NA |
| Brain injury | 11 (0.4) | 3 (1.9) | 8 (0.34) | 0.004 |
| Smoke inhalation | 4 (0.2) | 1 (0.6) | 3 (0.1) | 0.12 |
| Long-bone fractures | 5 (0.2) | 3 (1.9) | 2 (0.1) | <0.001 |
| Obesity (BMI > 30) | 598 (23.6) | 44 (28.2) | 554 (23.3) | 0.16 |
| Chemotherapy | 131 (5.2) | 10 (6.4) | 121 (5.1) | 0.47 |
| Diabetes mellitus | 733 (28.9) | 33 (21.1) | 700 (29.4) | 0.03 |
| Tobacco use | 0.83 | |||
| Never | 1177 (49.7) | 73 (51.4) | 1104 (49.6) | |
| Former | 652 (27.6) | 36 (25.4) | 616 (27.7) | |
| Current | 538 (22.7) | 33 (23.3) | 505 (22.7) | |
| Emergency surgery | 41 (1.6) | 5 (3.2) | 36 (1.5) | 0.10 |
| Tachypnea (RR > 30) | 239 (9.7) | 30 (20.0) | 209 (9.0) | <0.001 |
| Hypoxemia (SpO2 < 95%) | 861 (34.6) | 68 (44.2) | 793 (34.0) | 0.01 |
| FIO2 >0.35 | 395 (17.0) | 61 (41.2) | 334 (15.4) | <0.001 |
| Hypoalbuminemia | 695 (54.9) | 64 (74.4) | 631 (53.4) | <0.001 |
| Acidosis (pH < 7.35) | 231 (42.5) | 50 (55.6) | 181 (40.0) | 0.006 |
