Table 1 Patients’ characteristics at admission
Variable | Population N = 753 | No ICU-acquired infection (N = 579) | With ICU-acquired infection (N = 174) | P value | Alive (N = 592) | Dead (N = 161) | P value |
|---|---|---|---|---|---|---|---|
Age | 68 [56–78] | 67.6 [56–78] | 69 [55–77] | 0.4106 | 66.5 [55–77] | 71.5 [59–79] | 0.02 |
Men | 467 (62) | 342 (59) | 125 (72) | 0.0023 | 359 (61) | 108 (67) | 0.13 |
Length of stay (days) | 9 [6–18] | 7 [5–13] | 23 [14–37] | <.0001 | 9 [5–19] | 10 [7–17] | 0.18 |
Center | |||||||
A | 501 (66.5) | 402 (69) | 99 (57) | 0.0030 | 406 (69) | 95 (59.0) | 0.002 |
B | 105 (14) | 80 (14) | 25 (14) | 86 (14) | 19 (12) | ||
C | 35 (4.6) | 21 (3.6) | 14 (8.0) | 27 (4.6) | 8 (5.0) | ||
D | 112 (15) | 76 (13) | 36 (21) | 73 (12) | 39 (24) | ||
Admission category | 0.7400 | 0.003 | |||||
Medical | 596 (79) | 457 (19) | 139 (80) | 454 (77) | 142 (88) | ||
Unscheduled surgery | 104 (14) | 79 (14) | 25 (14) | 94 (16) | 10 (6) | ||
Scheduled surgery | 53 (7) | 43 (7) | 10 (6) | 44 (7) | 9 (6) | ||
Co-morbidities (Knaus definitions) | |||||||
Chronic hepatic failure | 45 (6.0) | 41 (7) | 4 (2.3) | 0.0196 | 30 (5) | 15 (9) | 0.044 |
Chronic cardiovascular failure | 101 (13.4) | 70 (12) | 31 (18) | 0.0519 | 70 (12) | 31 (19) | 0.014 |
Chronic respiratory failure | 157 (20.8) | 120 (21) | 37 (21) | 0.8780 | 126 (21) | 31 (19) | 0.57 |
Chronic renal failure | 61 (8.1) | 47 (8.1) | 14 (8.0) | 0.9758 | 44 (7.4) | 17 (10.6) | 0.19 |
Immunosuppression | 69 (9.2) | 54 (9.3) | 15 (8.6) | 0.7772 | 59 (10.0) | 10 (6.2) | 0.14 |
Long-term corticosteroids use | 24 (3.2) | 19 (3.3) | 5 (2.9) | 0.7882 | 20 (3.4) | 4 (2.5) | 0.57 |
History of chemotherapy | 40 (5.3) | 31 (5) | 9 (5.2) | 0.9254 | 31 (5) | 9 (5) | 0.86 |
Main reason of admission | |||||||
Coma | 106 (14) | 81 (14) | 25 (14) | 0.8999 | 81 (14) | 25 (15) | 0.55 |
Acute respiratory failure | 211 (28.0) | 150 (26) | 61 (35) | 0.0184 | 164 (27.7) | 47 (29) | 0.71 |
Septic shock | 154 (20.4) | 123 (21) | 31 (18) | 0.3257 | 121 (20) | 33 (20) | 0.99 |
Cardiogenic shock | 39 (5) | 14 (4) | 15 (8) | 0.0195 | 22 (4) | 17 (11) | 0.0005 |
Hemorrhage shock | 50 (6.6) | 40 (7) | 10 (6) | 0.5895 | 43 (7) | 7 (4) | 0.19 |
Multi-organ failure | 21 (3) | 11 (2) | 10 (6) | 0.0069 | 14 (2) | 7 (4) | 0.17 |
Shock (other) | 27 (3.6) | 23 (4) | 4 (2) | 0.2978 | 21 (3.5) | 6 (4) | 0.91 |
Other | 145 (19) | 127 (22) | 18 (10) | 0.0007 | 126 (21) | 19 (12) | 0.007 |
SAPS II score | 49 [37–60] | 48 [3–59] | 51 [40–62] | 0.0374 | 47 [36–57] | 57 [46–66] | <0.0001 |
SOFA score | 8 [5–11] | 8 [5–11] | 10 [7–12] | <.0001 | 7.5 [5–11] | 10 [7–12] | <0.0001 |
Cardiovascular SOFA score (>2) | 462 (61) | 333 (57) | 129 (74) | <.0001 | 333 (56) | 129 (80) | <0.0001 |
Mechanical ventilation | 559 (74) | 411 (71) | 148 (85) | 0.0002 | 422 (71) | 137 (85) | 0.0004 |
Antibiotic day 1 or 2 | 581 (77) | 448 (77) | 133 (76) | 0.80 | 455 (78) | 126 (78) | 0.71 |