From: Hemodynamic effects of short-term hyperoxia after coronary artery bypass grafting
Hemodynamic variables | T1 | T2 | T3 | Hyperoxia vs. normoxia | P value |
---|---|---|---|---|---|
Pre | Hyperoxia | Post | Adjusted change in estimate (95% CI) | ||
Central circulatory variablesa | |||||
MAP (mmHg) | 77 (11) | 85 (11)*** | 78 (11) | 6.76 (3.88; 9.63) | <0.0001 |
CVP (mmHg) | 9.1 (1.7) | 9.6 (1.7) | 9.3 (1.6) | 0.35 (0.11; 0.60) | 0.01 |
HR (beats min−1) | 84 (14) | 82 (14) | 83 (15) | −0.55 (−3.05; 2.06) | 0.68 |
Calculated variables | |||||
CO Modelflow (L min−1)b | 5.12 (1.04) | 4.97 (1.13) | 4.98 (1.18) | −0.08 (−0.27; 0.11) | 0.41 |
SVV (%)b | 13.6 (9.3) | 13.2 (6.9) | 15.3 (7.4) | −1.76 (−3.38; −0.03) | 0.05 |
PPV (%)b | 15.6 (10.3) | 15.1 (7.6) | 16.6 (4.9) | −1.30 (−2.99; 0.49) | 0.16 |
CO LiDCOplus (L min−1)c | 4.80 (1.10) | 4.62 (1.10) | 4.79 (1.27) | −0.12 (−0.40; 0.08) | 0.21 |
Derived parametersd | |||||
R sys (mmHg min L−1) | 13.4 (4.9) | 15.3 (5.9)*** | 13.6 (5.1) | 1.82 (0.96; 2.67) | <0.001 |
P vr (mmHg) | 11.7 (3.3) | 13.5 (3.5)* | 12.1 (2.8) | 1.47 (0.61; 2.37) | <0.01 |
R vr (mmHg min L−1) | 2.4 (0.8) | 2.8 (1.0)** | 2.5 (0.8) | 0.39 (0.21; 0.58) | <0.001 |
Slopevrc (L min−1 mmHg−1) | −0.46 (0.16) | −0.38 (0.13)** | −0.44 (0.15) | 0.07 (0.03; 0.10) | <0.001 |
P msf (mmHg) | 20.8 (3.5) | 23.1 (4.0)* | 21.4 (2.9) | 1.90 (0.95; 2.93) | <0.001 |
R vo (mmHg min L−1) | 7.9 (3.2) | 7.9 (4.3) | 7.7 (1.9) | −0.09 (−1.17; 1.03) | 0.87 |
Slopevoc (L min−1 mmHg−1) | 0.13 (0.05) | 0.15 (0.11) | 0.14 (0.04) | 0.01 (−0.03; 0.05) | 0.62 |
P cc (mmHg) | 38.8 (9.8) | 47.9 (15.1)* | 40.9 (8.9) | 8.55 (4.13; 12.68) | <0.001 |
Cerebral blood flowe | |||||
BFVmca (cm s−1) | 34.6 (10.6) | 32.3 (10.3) | 33.6 (11.5) | −1.42 (−3.80; 1.01) | 0.26 |
Pulsatility index | 0.95 | 0.96 | 1.0 | −0.03 (−0.07; 0.01) | 0.17 |
Resistance index | 0.57 | 0.57 | 0.58 | 0 (−0.01; 0.01) | 0.66 |
Microcirculationf | |||||
RBC filling (%) | 72.3 (4.4) | 71.1 (5.0) | 72.9 (5.1) | −1.87 (−3.29; −0.34) | 0.02 |
PBR (µm) | 2.1 (0.2) | 2.2 (0.2) | 2.1 (0.2) | 0.05 (−0.03; 0.12) | 0.21 |
TVD (mm/mm2) | 12.2 (3.5) | 12.7 (3.5) | 12.0 (3.4) | 0.35 (−0.96; 2.08) | 0.66 |
PVD (mm/mm2) | 12.0 (3.7) | 12.1 (2.9) | 12.0 (3.1) | −0.03 (−1.50; 1.70) | 0.97 |
VVD (µm/mm2) | 712 (117) | 672 (130) | 699 (93) | −37.29 (−80.97; 8.01) | 0.11 |
De Backer Score (n/mm) | 14.2 (1.2) | 15.1 (1.6) | 14.4 (1.6) | 0.86 (0.23; 1.51) | 0.01 |
PV (%) | 99.6 (1.3) | 93.2 (8.3)* | 97.4 (6.1) | −4.72 (−7.64; −2.00) | <0.01 |
100 (IQR 99–100) | 98 (IQR 85–100) | 100 (IQR 99–100) | – | – | |
Heterogeneity index (%) | 13 [9–14] | 22 [21–23]*** | 21 [15–21]*** | – | – |