IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study

Annals of Intensive Care

Table 2 Frequencies of alleles and genotypes for IL-6 rs1800795 polymorphism in septic shock patients compared to Iberian populations in Spain from 1000 Genomes Project data (http://www.1000genomes.org/1000-genomes-browsers) and SIRS patients

	SNP	IBS population	SIRS patients	Septic shock patients	p value^a	p value^b
N		107	263	202
HWE (p value)		–	0.430	0.750
Alleles	G	65%	63%	68%	0.684	0.306
Alleles	C	35%	37%	32%	–	–
Genotypes	GG	41.1%	40%	46%	0.481	0.229
	GC	47.7%	44%	45%	0.730	0.903
	CC	12.2%	15%	9%	0.490	0.071

p values were calculated by Chi-squared test: (a) differences between IBS population and septic shock patients, (b) differences between SIRS patients and septic shock patients
SIRS patients with systemic inflammatory response syndrome, IBS Iberian populations in Spain, HWE Hardy–Weinberg equilibrium, IL-6 interleukin-6