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Table 4 Risk of death regarding IL-6 rs1800795 polymorphism in septic shock patients who underwent major cardiac or abdominal surgery

From: IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study

 

Univariate

Multivariate

HR

95% CI

p value

aHR

95% CI

p value*

The first 7 days

 rs1800795 CC

3.42

1.36; 8.85

0.009

4.6

1.8; 12.1

0.002

 Cardiac surgery

   

7.9

0.9; 71.1

0.064

 Obesity

   

2.4

0.9; 6.3

0.069

 Alcoholism

   

3.6

1.1; 11.1

0.028

 APACHE-II score

   

1.1

1.1; 1.2

0.000

 Peritonitis

   

11.5

1.4; 97.4

0.025

The first 28 days

 rs1800795 CC

2.28

1.20; 4.34

0.012

2.5

1.3; 4.8

0.006

 Alcoholism

   

1.8

0.8; 3.7

0.135

 Emergency surgery

   

1.9

1.0; 3.6

0.050

 APACHE-II score

   

1.0

1.0; 1.1

0.052

 Peritonitis

   

2.3

1.3; 3.9

0.003

 Heart disease

   

2.0

1.2; 3.4

0.005

The first 90 days

 rs1800795 CC

2.20

1.23; 3.96

0.008

2.3

1.3; 4.1

0.006

 Emergency surgery

   

1.8

1.2; 2.9

0.008

 Peritonitis

   

1.9

1.2; 2.9

0.005

 Heart disease

   

1.7

1.1; 2.6

0.010

 Liver disease

   

2.0

0.9; 4.7

0.107

  1. IL-6 interleukin-6, HR hazard ratio, aHR adjusted hazard ratio, 95% CI 95% confidence interval, p value level of significance
  2. p values were calculated by Cox regression adjusting for the most important clinical and epidemiological characteristics (see “Statistical analysis” section). Statistically significant differences are shown in italics (p < 0.05)