From: Outcomes in elderly patients admitted to the intensive care unit with solid tumors
Overall (n = 262) | ICU survivors (n = 174) | ICU non-survivors (n = 88) | p value | |
---|---|---|---|---|
Reason for ICU admission [n (%)] | 0.42 | |||
Not related to cancer | 174 (66.4) | 120 (68.9) | 54 (61.4) | |
Related to anticancer drugs | 49 (18.7) | 29 (16.7) | 20 (22.7) | |
Related to cancer progression | 39 (14.9) | 25 (14.4) | 14 (15.9) | |
Reasons for ICU admission [n (%)] | <0.001 | |||
Sepsis | 80 (30.5) | 57 (32.8) | 3 (26.1) | |
Acute respiratory failure | 74 (28.2) | 47 (27) | 27 (30.8) | |
Coma or seizure | 21 (8) | 12 (6.9) | 9 (10.2) | |
Cardiorespiratory shock | 18 (6.9) | 1 (0.5) | 17 (19.3) | |
Hemorrhagic shock | 16 (6.1) | 14 (8.1) | 2 (2.3) | |
Acute kidney failure | 14 (5.3) | 10 (5.8) | 4 (4.6) | |
Acute heart failure | 10 (3.8) | 8 (4.6) | 2 (2.3) | |
Chronic bronchitis exacerbation | 8 (3.1) | 7 (4) | 1 (1.1) | |
Electrolytic disorders | 6 (2.3) | 5 (2.9) | 1 (1.1) | |
Hypovolemia | 5 (1.9) | 4 (2.3) | 1 (1.1) | |
Intentional overdose | 1 (0.4) | 1 (0.5) | 0 (0) | |
Post-surgery complications | 1 (0.4) | 1 (0.5) | 0 (0) | |
SAPS 2 score | 61.9 ± 22.5 | 51.4 ± 13.0 | 82.0 ± 22.9 | <0.001 |
Neutropenia | 19 (7.3) | 12 (6.9) | 7 (8) | 0.75 |
ICU stay and treatments | ||||
Time in ICU [days, median (IQR)] | 4 (2;7) | 4 (2;7)0 | 4 (1;8) | 0.26 |
Time in hospital [days, median (IQR)] | 14 (5;25) | 16 (8;27) | 6 (2;16) | <0.001 |
Mechanical ventilation | 135 (51.5) | 54 (31) | 81 (92.1) | <0.0001 |
Mechanical ventilation duration (days) | 3.5 ± 6.3 | 2.2 ± 4.4 | 6.2 ± 8.3 | <0.001 |
Noninvasive ventilation | 25 (10.3) | 20 (12.9) | 5 (5.7) | 0.08 |
Missing | 19 (7.3) | 19 (10.9) | 0 (0) | |
Inotropes | 126 (48.3) | 52 (30.1) | 74 (84.1) | <0.0001 |
Missing | 1 (0.4) | 1 (0.6) | 0 (0) | |
Inotropes duration (days) | 1.4 ± 2.4 | 0.8 ± 1.6 | 2.7 ± 3.1 | <0.001 |
Dialysis | 33 (12.6) | 17 (9.8) | 16 (18.2) | 0.05 |
Missing | 1 (0.4) | 1 (0.6) | 0 (0) | |
Limitation of active therapies [n (%)] | 46 (17.6) | 11 (6.3) | 35 (39.8) | <0.001 |