Table 1 Patients characteristics

Sex, number (%)

 F

16 (25.8)

 M

46 (74.2)

Age, years, median (IQR)

63 [54; 71]

Weight at Day 0, kg, median (IQR)

80 [73; 92]

BMI, median (IQR)

27.8 [24.3; 32.5]

Cause of admission, number (%)

 Sepsis

38 (61.3)

 Acute respiratory failure

9 (14.5)

 Coma

9 (14.5)

 Cardiogenic shock

6 (9.7)

 Renal replacement therapy

6 (9.7)

 Post-surgery

5 (8.1)

 Other

4 (6.5)

Type of ICU admission, number (%)

 Medical

33 (53.2)

 Surgical

29 (46.8)

Charlson comorbidity score, median (IQR)

2 [0; 4]

Comorbidities, number (%)

 None

22 (35.5)

 Diabetes mellitus

24 (38.7)

 Chronic heart failure

16 (25.8)

 Chronic renal disease

12 (19.4)

 Hemodialysis dependent

8 (12.9)

 COPD

8 (12.9)

 Cirrhosis

2 (3.2)

Creatinine base level, µmol/L, median [IQR]

93 [74; 117]

SAPS II, median [IQR]

56 [40; 73]

SOFA score at Day 0, median [IQR]

8 [6, 11]

Type of infection, number (%)

 Endocarditis of native valve

30 (48.4)

 Endocarditis of prosthetic valve

3 (4.8)

 Bacteremia without endocarditis

9 (14.5)

 Infusion catheter infection

6 (9.7)

 Pneumonia

9 (14.5)

 Mediastinitis

4 (6.5)

 Other

1 (1.6)

Bacteremia, number (%)

56 (90.3)

Weight on D-Day, kg, median [IQR]

88.5 [75.5; 98]

Daily dosing per kg, mg/kg, median [IQR]

105.5 [75; 150]

Plasma concentration, mg/L, median [IQR]

134.3 [65.3; 201]

Serum protein level, g/L

56 [51; 64]

Albuminemia, g/L

20 [13, 21]

Side effects attributed to overdose

 Delirium

8 (12.9)

 Persistent coma

3 (4.8)

 Acute renal failure

5 (8.1)

SOFA score on D-Day, median [IQR]

8 [6, 13]

Creatinine clearance on D-Day, mL/min

 <10 or hemodialysis

37 (59.7)

 10–30

7 (11.3)

 >30

18 (29.0)

Type of hemodialysis technique

 CVVHD

4 (12.5)