Systematic overdosing of oxa- and cloxacillin in severe infections treated in ICU: risk factors and side effects

Annals of Intensive Care

Table 2 Daily dosing and creatinine clearance

	Creatinine clearance (mL/min)
	<10	10–30	>30	p*
	n = 37	n = 7	n = 18	p*
Dosing per 24 h, g, median [IQR]	8 [6–10]	6 [6–12]	12 [10–12]	0.002
Dosing per kg per day, median [IQR]	87.0 [75.0–120.5]	100.0 [52.6–155.8]	131.7 [108.1–160.0]	0.033