Table 3 Statistical analysis—univariate analysis
Trough concentration ≤50 | Trough concentration >50 mg/L | OR | IC 95% | p value | |
|---|---|---|---|---|---|
n = 10 | n = 52 | – | – | ||
Age | 59.5 [53; 67] | 63 [54; 72] | 1.026 | [0.98; 1.08] | 0.29 |
BMI | 26.1 [22.8; 29.1] | 28.4 [24.6; 32.8] | 1.110 | [0.96; 1.29] | 0.17 |
Indication for ICU admission | |||||
Sepsis | 4 (40) | 34 (65.4) | 2.833 | [0.71; 11.35] | 0.14 |
Creatinine base level | 91 [70; 96] | 94 [75; 120] | 1.001 | [1; 1.01] | 0.69 |
Hemodialysis dependence | 1 (10) | 7 (13.5) | 1.400 | [0.15; 12.81] | 0.77 |
SAPS II | 52 [36; 73] | 56 [40; 71] | 1.002 | [0.97; 1.04] | 0.92 |
SOFA score on Day 0 | 7 [4, 10] | 9 [6, 11] | 1.151 | [0.93; 1.42] | 0.20 |
SOFA score on Day 0 without renal failure | 7 [3, 9] | 7 [5, 8] | 1.068 | [0.86; 1.33] | 0.55 |
Type of infection | |||||
Infective endocarditis | 2 (20) | 31 (59.6) | 8.611 | [1.42; 52.09] | 0.02 |
Other intravascular infection | 3 (30) | 12 (23.1) | 2.222 | [0.42; 11.83] | 0.35 |
Other infection | 5 (50) | 9 (17.3) | 1.000 | 0.06 | |
Bacteremia | 7 (70) | 49 (94.2) | 7.001 | [1.17; 41.75] | 0.03 |
Daily dosing per kg, mg/kg | 101.3 [75.9; 111.1] | 108.1 [75; 150] | 1.007 | [0.99; 1.02] | 0.43 |
Time lag between treatment initiation and D-Day, d, median [IQR] | 5 [3, 7] | 6.5 [4; 12.5] | 1.099 | [0.95; 1.27] | 0.19 |
SOFA on D-Day | 7 [4, 8] | 9 [6, 14] | 1.256 | [1.01; 1.56] | 0.04 |
SOFA on D-Day without renal failure | 5 [3, 7] | 6.5 [4, 10] | 1.140 | [0.93; 1.4] | 0.22 |
SOFA > 7 on D-Day without renal failure | 2 (20) | 23 (44.2) | 3.172 | [0.61; 16.41] | 0.17 |
Creatinine clearance on D-Day, mL/min | |||||
<10 or RRT | 2 (20) | 35 (67.3) | 11.136 | [2.01; 61.65] | <0.01 |
10–30 | 1 (10) | 6 (11.5) | 3.818 | [0.38; 38.83] | 0.26 |
>30 | 7 (70) | 11 (21.2) | 1.000 | 0.02 | |
Aminoglycosides | 4 (40) | 27 (51.9) | 1.620 | [0.41; 6.42] | 0.49 |
Serum protein level on D-Day, g/L | 0.944 | [0.88; 1.01] | 0.11 | ||