Table 1 Clinical characteristics and predictors of 12-month mortality in 84 admissions to a general ICU with a diagnosis of cirrhosis
From: Long-term outcome of patients with liver cirrhosis admitted to a general intensive care unit
All admissions (n = 84) | 12 m survivors (n = 43) | 12 m nonsurvivors (n = 41) | p value | |
|---|---|---|---|---|
Age (mean ± SD, range)* | 50.2 ± 11.2 | 47.4 ± 10.1 | 53.1 ± 11.8 | 0.020 |
Male gender (n) | 59 (70.2%) | 32 (74.4%) | 27 (65.9%) | 0.391 |
SIMD quintile | 1 (1–2) | 1 (1–2) | 1 (1–2) | 0.755 |
Social deprivationa (n) | 56 (66.7%) | 31 (72.1%) | 25 (61.0%) | 0.356 |
Alcohol-related disease (n) | 70 (83.3%) | 36 (83.7%) | 34 (82.9%) | 0.922 |
Ventilated on admission (n) | 58 (69.0%) | 30 (69.8%) | 28 (68.3%) | 0.884 |
Readmission during same hospital stay* | 16 (19.0%) | 13 (30.2%) | 3 (7.3%) | 0.008 |
ICU admission reason | 0.114 | |||
Pneumonia | 19 (22.6%) | 12 (27.9%) | 7 (17.1%) | |
GI haemorrhage | 11 (13.1%) | 6 (14.0%) | 5 (12.2%) | |
ARDS | 8 (9.5%) | 4 (9.3%) | 4 (9.8%) | |
Sepsis | 7 (8.3%) | 2 (4.7%) | 5 (12.2%) | |
Encephalopathy | 5 (6.0%) | 3 (7.0%) | 2 (4.9%) | |
GI perforation | 5 (6.0%) | 0 (0.0%) | 5 (12.2%) | |
Trauma/burns | 5 (6.0%) | 3 (7.0%) | 2 (4.9%) | |
Decompensated cirrhosis | 4 (4.8%) | 0 (0.0%) | 4 (9.8%) | |
Seizures | 4 (4.8%) | 3 (7.0%) | 1 (2.4%) | |
Otherb | 10 (11.9%) | 5 (6%) | 5 (6%) | |
Drug related | 4 (4.8%) | 4 (4.8%) | 0 (0%) | |
Pancreatitis | 2 (2.4%) | 1 (1.2%) | 1 (1.2%) | |
Length of ICU stay | 5 (1–12.8) | 7 (2–13) | 5 (1–12.5) | 0.243 |
Sodium (mEq L−1) | 136.0 (132.0–140.8) | 138.0 (135.0–142.0) | 133 (131–140) | 0.066 |
Potassium (mEq L−1) | 3.9 (3.6–4.5) | 3.9 (3.6–4.3) | 3.9 (3.5–4.8) | 0.809 |
Urea (mmol L−1) | 8.1 (4.1–12.8) | 7.1 (4.1–11.6) | 9.2 (4.9–14.7) | 0.123 |
Lactate* (mmol L−1) | 1.9 (1.3–2.9) | 1.5 (1.1–2.1) | 2.4 (1.7–5.4) | <0.001 |
Bilirubin* (µmol L−1) | 45.5 (20.8–108.3) | 28 (14–70) | 71 (41–198) | <0.001 |
Creatinine* (µmol L−1) | 81.5 (57.3–162.3) | 71 (57–114) | 131 (63.5–197) | 0.029 |
White cell count (×10−9 L−1) | 12.4 (7.9–17) | 13.3 (8.4–17.4) | 7.45 (10.6–18.6) | 0.466 |
Albumin* (g L−1) | 20 (17–26) | 23 (19–28) | 18 (15.5–22) | 0.002 |
PT ratio* | 1.5 (1.2–2.0) | 1.4 (1.1–1.7) | 1.7 (1.5–2.5) | <0.001 |
Platelet count* (×10−9 L−1) | 109.5 (81.5–180.8) | 133 (88–215) | 94 (59.5–144) | 0.005 |
PaO2/FiO2 ratio (kPa) | 21.7 (12.4–36.1) | 28.3 (14.5–38.9) | 18.2 (11.8–32.6) | 0.070 |
Glasgow coma score | 10.5 (3–15) | 10 (5–14) | 11 (3–15) | 0.873 |
Ascites (n) | 35 (41.7%) | 14 (32.6%) | 21 (51.2%) | 0.083 |
Encephalopathy (n) | 29 (34.5%) | 13 (30.2%) | 16 (39.0%) | 0.397 |