Table 2 Blood gases, hemodynamic, ventilation, and metabolic parameters before and after hyperventilation
| Â | Baseline | Hyperventilation | p value |
|---|---|---|---|
PaCO2 [median (IQR), mmHg] | 44 [41–48] | 34 [30–38] | <0.001 |
PcvCO2 [median (IQR), mmHg] | 49 [46–53] | 42 [38–44] | <0.001 |
∆PCO2 (mean ± SD, mmHg) | 4.7 ± 1.0 | 7.0 ± 2.6 | <0.001 |
∆PCO2 ≤ 6 mmHg [n (%)] | 17 (94.4) | 8 (44.4) | 0.004 |
Arterial pH (mean ± SD) | 7.35 ± 0.07 | 7.42 ± 0.09 | <0.001 |
Central venous pH (mean ± SD) | 7.33 ± 0.07 | 7.39 ± 0.08 | <0.001 |
Bicarbonate (mean ± SD, mmol/L) | 25.6 ± 1.8 | 24.9 ± 1.6 | <0.001 |
Base excess (mean ± SD, mmol/L) | 0.1 ± 2.1 | 0.6 ± 2.1 | 0.002 |
PaO2/FiO2 (mean ± SD, mmHg) | 210 ± 88 | 205 ± 92 | 0.64 |
CI (mean ± SD, L/min/m2) | 3.03 ± 0.79 | 3.00 ± 0.78 | 0.27 |
Heart rate [median (IQR), beats/min] | 85 [79–90] | 86 [78–88] | 0.70 |
Stroke index (mean ± SD, mL/m2) | 36.2 ± 10.1 | 35.4 ± 10.3 | 0.25 |
MAP (mean ± SD, mmHg) | 77 ± 8 | 79 ± 10 | 0.10 |
ScvO2 (mean ± SD, %) | 73 ± 6 | 67 ± 8 | <0.001 |
DO2 (mean ± SD, mL/min/m2) | 396 ± 121 | 395 ± 114 | 0.62 |
VO2 [median (IQR), mL/min/m2] | 93 [76–105] | 112 [95–134] | 0.002 |
OE (mean ± SD, %) | 24.5 ± 5.8 | 31.4 ± 8.1 | <0.001 |
Lactate (mean ± SD, mmol/L) | 1.15 ± 0.47 | 1.35 ± 0.50 | <0.001 |
SVRI (mean ± SD, dynes s/m2/cm5) | 1645 ± 379 | 1940 ± 464 | <0.001 |
Tidal volume [median (IQR), mL] | 455 [430–500] | 450 [430–500] | 0.08 |
Respiratory rate [median (IQR), breaths/min] | 20 [18–20] | 30 [28–30] | <0.001 |
Minute ventilation (mean ± SD, L/min) | 8.3 ± 1.6 | 12.6 ± 2.2 | <0.001 |
Plateau pressure (mean ± SD, cm H2O) | 23.5 ± 3.7 | 23.1 ± 4.7 | 0.60 |
Temperature (mean ± SD, °C) | 37.1 ± 0.6 | 37.2 ± 0.6 | 0.21 |