Fig. 3

Changes in renal oxygen consumption following loop diuretics. In human or animal, use of diuretics is associated with higher renal medulla PO2 (mmHg), lower R2* BOLD MRI signal (Hz, 1/s) suggesting a higher oxygenation and lower renal oxygen consumption (RVO2, ml/min) in various conditions. *Results from selected studies (Brezis et al. Am J Physiol Renal Physiol 1994; Textor et al. J Am Soc Nephrol 2009; Warner et al. Invest Radiol 2011; Redfors et al. Intensive Care Med 2009; Sward et al. Intensive Care Med 2005). R2* is believed to be correlated with deoxyhemoglobin and therefore inversely correlated with tissue oxygenation