First author, year | N | RRT modality | Qf or Qd (l/h) | Cutoffa (kDa) | Cytokine clearance | Albumin clearance | Clinical effects |
---|---|---|---|---|---|---|---|
Morgera et al. [103] | 24 | CVVH versus CVVHD | Qf 1 versus 2.5 Qd 1 versus 2.5 | 60 | Greater IL-1ra clearance with CVVH. Increased Qf or Qd increased IL-6 and IL-1ra clearance | Highest with CVVH 2.5 l/h | Overall decrease in APACHE II and MODS scores. No difference between groups |
Morgera [235] | 30 | CVVH | Qf 2.5 | 30 versus 60 | Greater IL-6 and IL-1ra clearance with 60 kDa-filter | Plasma albumin levels not affected by filter cutoff | Reduced noradrenaline requirements with 60 kDa-filter |
Haase et al. [104] | 10 | IHD | Qd 18 | 20 versus 60 | Greater IL-6, IL-8 and IL-10 clearance with 60 kDa-filter | Plasma albumin levels not affected by filter cutoff | Trend toward increased mean arterial pressure and reduced vasopressor requirements with 60 kDa-filter |