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Table 2 Comparison of organ failures and septic shock treatment according to survival

From: Outcome of patients with septic shock and high-dose vasopressor therapy

Variables All patients (n = 106) Survivors at D28 (n = 42) Non-survivors at D28 (n = 64) p
Organ failure scores     
 SOFA (admission) (mean ± SD) 12 ± 3 11 ± 3 13 ± 3 0.002
 SOFA (day 2) (mean ± SD) 12 ± 4 10 ± 4 13 ± 4 0.01
 SOFA (day 5) (mean ± SD) 8 ± 5 6 ± 5 12 ± 5 <0.001
Hemodynamic failure     
 Mean arterial pressure (MAP) at admission (mmHg) (mean ± SD) 69 ± 20 69 ± 18 70 ± 21 0.69
 Heart rate (beats per minute) (mean ± SD) 112 ± 26 106 ± 25 115 ± 27 0.12
 Cardiac index (l/min/m2) (mean ± SD) 3.0 ± 0.86 3.0 ± 0.23 2.9 ± 0.13 0.64
 Failure to achieve target MAP > 65 mmHg within 6 first hours [n (%)] 13 (12.2) 1 (2.4) 12 (18.8) 0.02
 Initial fluid therapy (mL/kg) (mean ± SD) 29.7 ± 22.7 33.4 ± 23.6 28.2 ± 22.4 0.37
 Stress-dose corticosteroids [n (%)] 89 (84) 40 (95.2) 49 (76.6) 0.04
Respiratory failure     
 Mechanical ventilation [n (%)] 93 (88.6) 34 (81) 59 (93.7) 0.05
 PaO2/FiO2 ratio (mmHg) [median (Q25–Q75)] 109 (77–200) 154 (87–228) 95 (68–167) 0.05
 ARDS [n (%)] 43 (40.6) 11 (26.2) 32 (50) 0.01
 Length of ventilation (days) [median (Q25–Q75)] 3.5 (1.3–8) 6.5 (3.8–10.3) 2 (1–7) 0.01
Renal failure     
 Renal replacement therapy (RRT) [n (%)] 61 (57.5) 22 (52.4) 39 (60.9) 0.38
Metabolic parameters at admission     
 pH (mean ± SD) 7.28 ± 0.15 7.29 ± 0.14 7.28 ± 0.16 0.62
 Bicarbonates (mmol/l) (mean ± SD) 18.1 ± 5.6 18.0 ± 5.7 18.1 ± 5.6 0.96
 Lactate (mmol/L) (mean ± SD) 4.8 ± 3.8 4.1 ± 2.6 5.4 ± 4.3 0.06
 Lactate clearance H0–H6 (mmol/l) (mean ± SD) 0.15 ± 2.45 0.3 ± 2.0 0.0 ± 2.7 0.68
 Maximal lactate concentration (mmol/l) (mean ± SD) 6.8 ± 4.4 5.3 ± 3.2 7.8 ± 4.9 0.004
 SVO2 (%) (mean ± SD) 74.5 ± 11.4 75.4 ± 9.8 73.8 ± 12.6 0.569
Adequate antibiotherapy (mean ± SD) 98 (92.4) 39 (92.8) 59 (92.2) 0.85