Table 2 Comparison of organ failures and septic shock treatment according to survival
From: Outcome of patients with septic shock and high-dose vasopressor therapy
Variables | All patients (n = 106) | Survivors at D28 (n = 42) | Non-survivors at D28 (n = 64) | p |
|---|---|---|---|---|
Organ failure scores | ||||
SOFA (admission) (mean ± SD) | 12 ± 3 | 11 ± 3 | 13 ± 3 | 0.002 |
SOFA (day 2) (mean ± SD) | 12 ± 4 | 10 ± 4 | 13 ± 4 | 0.01 |
SOFA (day 5) (mean ± SD) | 8 ± 5 | 6 ± 5 | 12 ± 5 | <0.001 |
Hemodynamic failure | ||||
Mean arterial pressure (MAP) at admission (mmHg) (mean ± SD) | 69 ± 20 | 69 ± 18 | 70 ± 21 | 0.69 |
Heart rate (beats per minute) (mean ± SD) | 112 ± 26 | 106 ± 25 | 115 ± 27 | 0.12 |
Cardiac index (l/min/m2) (mean ± SD) | 3.0 ± 0.86 | 3.0 ± 0.23 | 2.9 ± 0.13 | 0.64 |
Failure to achieve target MAP > 65 mmHg within 6 first hours [n (%)] | 13 (12.2) | 1 (2.4) | 12 (18.8) | 0.02 |
Initial fluid therapy (mL/kg) (mean ± SD) | 29.7 ± 22.7 | 33.4 ± 23.6 | 28.2 ± 22.4 | 0.37 |
Stress-dose corticosteroids [n (%)] | 89 (84) | 40 (95.2) | 49 (76.6) | 0.04 |
Respiratory failure | ||||
Mechanical ventilation [n (%)] | 93 (88.6) | 34 (81) | 59 (93.7) | 0.05 |
PaO2/FiO2 ratio (mmHg) [median (Q25–Q75)] | 109 (77–200) | 154 (87–228) | 95 (68–167) | 0.05 |
ARDS [n (%)] | 43 (40.6) | 11 (26.2) | 32 (50) | 0.01 |
Length of ventilation (days) [median (Q25–Q75)] | 3.5 (1.3–8) | 6.5 (3.8–10.3) | 2 (1–7) | 0.01 |
Renal failure | ||||
Renal replacement therapy (RRT) [n (%)] | 61 (57.5) | 22 (52.4) | 39 (60.9) | 0.38 |
Metabolic parameters at admission | ||||
pH (mean ± SD) | 7.28 ± 0.15 | 7.29 ± 0.14 | 7.28 ± 0.16 | 0.62 |
Bicarbonates (mmol/l) (mean ± SD) | 18.1 ± 5.6 | 18.0 ± 5.7 | 18.1 ± 5.6 | 0.96 |
Lactate (mmol/L) (mean ± SD) | 4.8 ± 3.8 | 4.1 ± 2.6 | 5.4 ± 4.3 | 0.06 |
Lactate clearance H0–H6 (mmol/l) (mean ± SD) | 0.15 ± 2.45 | 0.3 ± 2.0 | 0.0 ± 2.7 | 0.68 |
Maximal lactate concentration (mmol/l) (mean ± SD) | 6.8 ± 4.4 | 5.3 ± 3.2 | 7.8 ± 4.9 | 0.004 |
SVO2 (%) (mean ± SD) | 74.5 ± 11.4 | 75.4 ± 9.8 | 73.8 ± 12.6 | 0.569 |
Adequate antibiotherapy (mean ± SD) | 98 (92.4) | 39 (92.8) | 59 (92.2) | 0.85 |