Table 3 Characteristics of vasopressor therapy according to survival
From: Outcome of patients with septic shock and high-dose vasopressor therapy
Characteristics of vasopressor therapy | All patients (n = 106) | Survivors at day 28 (n = 42) | Non-survivors at day 28 (n = 64) | p |
|---|---|---|---|---|
Maximum dose (mg/h) (mean ± SD) | 14.70 ± 11.3 | 10.55 ± 7.74 | 17.46 ± 12.51 | 0.002 |
Weight-based maximum dose (µg/kg/min) (mean ± SD) | 3.28 ± 2.41 | 2.26 ± 1.55 | 3.97 ± 2.65 | <0.001 |
Cumulative dose (mg) (mean ± SD) | 291.33 ± 342.84 | 332 ± 438 | 263 ± 261 | 0.32 |
Weight-based cumulative dose (µg/kg) (mean ± SD) | 3828 ± 4300 | 4222 ± 5389 | 3565 ± 3410 | 0.45 |
Mean dose (mg/h) (mean ± SD) | 5.34 ± 4.73 | 3.32 ± 2.93 | 6.68 ± 5.22 | <0.001 |
Weight-based mean dose (µg/kg/min) (mean ± SD) | 1.20 ± 1.05 | 0.72 ± 0.61 | 1.52 ± 1.16 | <0.001 |
First 24-h mean dose (mg/h) (mean ± SD) | 7.01 ± 6.89 | 5.05 ± 3.90 | 8.30 ± 8.06 | 0.02 |
First 24-h weight-base mean dose (µg/kg/min) (mean ± SD) | 1.57 ± 1.52 | 1.12 ± 0.87 | 1.86 ± 1.77 | 0.01 |
Peak 6-h mean dose (mg/h) (mean ± SD) | 9.96 ± 6.89 | 7.70 ± 6.56 | 11.44 ± 6.75 | 0.006 |
Peak 6-h weight-based mean dose (mean ± SD) | 2.26 ± 1.57 | 1.69 ± 1.33 | 2.64 ± 1.61 | 0.002 |
Duration of treatment (h) (mean ± SD) | 84.66 ± 106.13 | 81.79 ± 48.30 | 86.57 ± 131.69 | 0.82 |