Table 1 Baseline characteristics of the ICU and non-ICU ANCA-associated vasculitis groups
ICU-AAV (n = 97) | Non-ICU-AAV (n = 95) | p | |
|---|---|---|---|
Baseline characteristics | |||
Sex (M/F) | 45/52 | 54/41 | 0.147 |
Age (years) | 62.0 (48.0–71.0) | 68.0 (55.8–75.1) | 0.016 |
Weight (kg) | 71.5 (58.0–80.0) | 70.0 (60.0–82.0) | 0.877 |
Hypertension, n (%) | 35 (36.1) | 47 (49.5) | 0.061 |
Diabetes mellitus, n (%) | 11 (11.3) | 9 (9.5) | 0.672 |
AAV characteristics | |||
Diagnosis, n (%) | |||
GPA | 58 (59.8) | 45 (47.4) | 0.084 |
MPA | 37 (38.1) | 48 (50.5) | 0.084 |
EGPA | 2 (2.1) | 2 (2.1) | 0.983 |
ANCA type | |||
By immunofluorescence | |||
cANCA, n (%) | 61 (62.9) | 33 (34.7) | <0.001 |
pANCA, n (%) | 36 (37.1) | 62 (65.3) | <0.001 |
By ELISA | |||
PR3-ANCA, n (%) | 60 (61.9) | 30 (31.6) | <0.001 |
MPO-ANCA, n (%) | 37 (38.1) | 65 (68.4) | <0.001 |
Disease status, n (%) | |||
Newly diagnosed AAV, n (%) | 77 (79.4) | 88 (92.6) | 0.008 |
Relapsing AAV, n (%) | 20 (20.6) | 7 (7.4) | 0.008 |
BVAS | 23.0 (18.0–27.5) | 19.5 (15.0–31.0) | 0.273 |
Organ involvement, n (%) when specified | |||
Cutaneous signs | 25 (25.8) | 19 (20.0) | 0.341 |
Ear, nose, throat | 36 (37.1) | 34 (35.8) | 0.849 |
Heart | 17 (17.5) | 3 (3.2) | 0.001 |
Digestive | 9 (9.3) | 3 (3.2) | 0.134 |
Lung | 85 (87.6) | 30 (31.6) | <0.001 |
Alveolar hemorrhage | 62 (63.9) | 9 (9.5) | <0.001 |
Others | 23 (23.7) | 21 (22.1) | 0.791 |
Renal | 83 (85.6) | 87 (91.6) | 0.191 |
Serum creatinine | 256.5 (115.3–527.8) | 244.0 (132.0–377.5) | 0.666 |
Renal replacement therapy | 55 (56.7) | 19 (20.0) | <0.001 |
Neurological | 25 (25.8) | 12 (12.6) | 0.020 |
Central | 8 (8.2) | 0 (0) | 0.007 |
Peripheral | 17 (17.5) | 12 (12.6) | 0.343 |