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Annals of Intensive Care

Table 3 Comparison between survivor and non-survivor ICU-AAV patients and univariate logistic regression analysis for ICU mortality

From: Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study

 

Survivors (n = 82)

Non-survivors (n = 15)

p value

Univariate logistic regression

OR

95% CI

p

Baseline characteristics

 Gender (female), n (%)

41 (50)

4 (26.7)

0.158

0.36

0.11–1.24

0.105

 Age (years), median [IQR]

61.0 [47.0–70.3]

67.0 [65.0–75.0]

0.212

0.98

0.94–1.02

0.311

 Hypertension, n (%)

32 (39.0)

3 (20.0)

0.158

0.39

0.10–1.49

0.169

 ANCA

      

  c-ANCA type, n (%)

54 (65.9)

7 (46.7)

0.157

0.45

0.15–1.38

0.164

 AAV relapse, n (%)

19 (23.2)

1 (6.7)

0.185

0.24

0.03–1.92

0.177

AAV involvement

 Heart, n (%)

14 (17.1)

3 (20.0)

0.723

1.21

0.30–4.87

0.784

 CNS, n (%)

5 (6.1)

3 (20.0)

0.104

3.85

0.81–18.2

0.089

 Digestive, n (%)

7 (8.5)

2 (13.3)

0.626

1.64

0.31–8.83

0.559

 ENT, n (%)

33 (40.2)

3 (21.4)

0.159

0.37

0.10–1.41

0.147

Kidney

  Serum creatinine (µmol/L), median [IQR]

364.0 [117.5–503.0]

229.0 [104.0–682.0]

0.824

1.00

0.99–1.00

0.878

  AKIN > 1, n (%)

74 (90.2)

15 (100)

0.351

1.51

0.17–13.1

0.706

  RRT, n (%)

43 (52.4)

12 (80.0)

0.086

3.53

0.93–13.5

0.064

 Lung, n (%)

71 (86.6)

14 (93.3)

0.685

2.17

0.26–18.2

0.475

  DAH, n (%)

51 (62.2)

11 (73.3)

0.562

1.67

0.49–5.71

0.412

  Respiratory assistance, n (%)

52 (63.4)

14 (93.3)

0.032

8.51

1.07–67.9

0.043

Infectious event, n (%)

26 (31.7)

13 (86.7)

<0.001

14.0

2.94–66.6

0.001

Vasopressors, n (%)

17 (20.7)

9 (60.0)

0.002

5.73

1.79–18.4

0.003

Plasma exchange*, n (%)

39 (47.6)

7 (46.7)

0.949

0.96

0.32–2.91

0.949

Cyclophosphamide*, n (%)

52 (63.4)

14 (93.3)

0.032

8.51

1.07–67.9

0.043

SAPS II, median [IQR]

37.5 [28.8–49.3]

52.0 [33.0–66.0]

0.006

1.06

1.02–1.10

0.003

SOFA, median [IQR]

6.0 [4.0–9.0]

8.0 [6.0–13.0]

0.040

1.21

1.04–1.41

0.013

BVAS, median [IQR]

23.0 [18.0–28.0]

21.0 [20.0–27.0]

0.916

1.01

0.94–1.08

0.899

  1. OR odd ratio, CI confidence interval, ANCA anti-neutrophil cytoplasmic antibodies, c-ANCA cytoplasmic ANCA, AAV ANCA-associated vasculitis, CNS central nervous system, ENT ear nose throat, AKIN acute kidney injury network score, RRT renal replacement therapy, DAH diffuse alveolar hemorrhage
  2. * Started before or during the ICU stay
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