The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure

Annals of Intensive Care

Table 3 Multivariate logistic regression analysis to evaluate the association between immunoglobulins and the risk of mortality at the ICU in the group of patients with SOFA score <8

Immunoglobulins	SOFA < 8
	A. Patients with prior immunosuppression included (n = 122)				B. Patients with prior immunosuppression excluded (n = 99)
	OR	CI 95%		p	OR	CI 95%		p
IgG (total) < 407 mg/dl	7.29	1.62	32.79	0.010	9.02	1.45	56.30	0.019
IgG1 < 332 mg/dl	8.02	1.82	35.32	0.006	8.95	1.44	55.79	0.019
IgG2 < 10 mg/dl	3.71	0.93	14.80	0.064	6.22	1.08	35.72	0.040
ISC IgGAM = 0	13.79	2.61	72.98	0.002	17.53	2.23	137.57	0.006

Adjusting variables for A. were (diabetes mellitus) (presence of prior immunosuppression) (APACHE-II score) (presence of respiratory infection), (microbiologically confirmed infection). Adjusting variables for B. were (APACHE-II score) (presence of respiratory infection), (presence of abdominal infection) (microbiologically confirmed infection)