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Table 2 Biochemical variables, glycemic therapy and nutrition

From: The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes

Variable

All patients (n = 45)

Non-insulin group (n = 25)

Insulin group (n = 20)

P

Blood glucose level (mmol/l)

 Day 1

9.9 (7.0, 11.0)

7.9 (6.4, 10.0)

11.0 (9.8, 12.0)

<0.001

 Day 2

9.8 (8.1, 12.0)

8.7 (6.8, 11.0)

12.0 (9.7, 16.0)

<0.001

Plasma C-peptide level (nmol/l)

 Day 1

1.3 (0.8, 2.9)

1.6 (0.9, 2.3)

0.9 (0.3, 3.0)

0.19

 Day 2

1.6 (0.9, 2.3)

1.7 (1.3, 2.1)

1.3 (0.6, 3.4)

0.29

Creatinine level (µmol/l)

 Day 1

127 (73, 195)

105 (68, 195)

138 (91, 189)

0.55

 Day 2

113 (73, 216)

92 (61, 216)

117 (90, 222)

0.49

Ketonemia, n (%)a

 Day 1

12/34 (35.3%)

6/18 (33.3%)

6/16 (37.5%)

0.80

 Day 2

11/36 (30.6%)

8/19 (42.1%)

3/17 (17.6%)

0.16

Ketonuria, n (%)b

 Day 1

3/34 (8.8%)

0/18

3/16 (18.8%)

 Day 2

3/36 (8.3%)

2/19 (10.5%)

1/17 (5.9%)

1.0

Insulin therapy, n (%)

 Before day 1

13 (28.9%)

4 (16.0%)

9 (45.0%)

0.049

 Between day 1 and day 2

20 (44.4%)

0

20 (100%)

 Total dose in treated, units

24 (14, 46)

Any insulin secretagoguec

 Before day 1

3 (7)

1 (4)

2 (10)

0.58

 Between day 1 and day 2

7 (16)

2 (8)

5 (25)

0.21

Enteral nutrition, n (%)d

 Day 1

2 (4.4%)

1 (4.0%)

0

 Day 2

9 (20.0%)

6 (24.0%)

3 (15.0%)

0.71

Parenteral nutrition, n (%)d

 Day 1

1 (2.2%)

0

1 (5.0%)

 Day 2

2 (4.4%)

1 (4.0%)

1 (5.0%)

1.0

  1. Values are median (IQR) or n (%)
  2. aBlood ketone level ≥0.6 mmol/l
  3. bUrine ketone level ≥1 mmol/l
  4. cSulfonylureas and/or dipeptidyl peptidase-4 inhibitors
  5. dOngoing nutrition at the time of c-peptide measurement