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Annals of Intensive Care

Table 4 Multivariable linear regression analysis of the association with c-peptide change (%) from ICU admission to the next-day value

From: The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes

Variable

Univariable analysis

Multivariable analysis

Crude estimate (95% CI)

P value

Adjusted estimateb (95% CI)

P value

Insulin administrationa

 No

Reference

 

Reference

 

 Yes

55.2 (2.0 to 108.4)

0.04

45.9 (2.8 to 89.0)

0.04

Insulin-requiring diabetes

 No

Reference

 

Reference

 

 Yes

7.0 (−55.7 to 69.8)

0.82

−59.7 (−111.2 to −8.2)

0.02

Blood glucose change, per  %

1.2 (0.7 to 1.6)

<0.001

1.3 (0.8 to 1.8)

<0.001

  1. aIntravenous and/or subcutaneous insulin administered between ICU day 1 and ICU day 2
  2. bHbA1c level, creatinine level, APACHE III score and administration of insulin secretagogues were not retained in the model. Backward selection was used to include variables with P < 0.1 in the final model
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