Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome

Annals of Intensive Care

Table 2 List of included studies

Study	Year	Centre	Type	Patients	Population	P/F ratio	MV (days)	Prone (%)	LIS	Age (years)	Heparin coating	Membrane type	Pump type	Coagulation ratio^b	Max cannula size (French)	Cannulation	ECMO duration (days)
Mols et al. [59]	2000	University of Freiburg, Freiburg, Germany	CP	62	Mixed	64	10	81	3.2	35	Y	n/a	R	1.26	25	F-J	14.5
Davies et al. [36]	2009	Multicentre, Australia	CR	68	H1N1	56	2	18	3.2	34^a	Y	HF-PMP	C	n/a	n/a	Mixed	10^a
Mueller et al. [60]	2009	University Medical Center, Regensburg, Germany	CR	60	Mixed	64	1	n/a	3.6	53^a	Y	HF-PMP	C	1.50	23	F-J	9^a
Peek et al. [8]	2010	The Glenfield Hospital, Leicester, UK	RCT	68	Mixed	70^a	1.5^a	47	3.5^a	40	n/a	HF-PP	R	1.58	n/a	n/a	9^a
Noah et al. [61]	2011	Multicentre, UK	CC	69	H1N1	55^a	4^a	39	3.5^a	36	n/a	n/a	n/a	n/a	23	n/a	9^a
Patroniti et al. [62]	2011	Multicentre, Italy	CP	60	ARDS	63^a	2	27	3.6	41	Y	HF-PMP	C	1.6	n/a	Mixed	9^a
Schmidt et al. [27]	2013	Multicentre, France	CR	140	Mixed	53	5	61	n/a	44^a	Y	HF mixed	C	1.357	n/a	Mixed	15^a
Roch et al. [63]	2014	Marseille North Hospital, France	CP	85	Mixed	60	2	20	3.5	47	Y	HF mixed	C	1.28	25	F-J	9
Haneya et al. [64]	2015	University Medical Center, Regensburg, Germany	CR	262	Mixed	64	1	n/a	3.3	49	Y	HF mixed	C	1.57	31	Mixed	9
Schmidt et al. [24] (Melbourne)	2015	Alfred Hospital, Australia	CR	52	Mixed	75	1	2	n/a	37	n/a	n/a	n/a	n/a	n/a	Mixed	10
Schmidt et al. [24] (Paris)	2015	Pitié-Salpètrière Hospital, France	CR	57	Mixed	61	4	20	n/a	46	n/a	n/a	n/a	n/a	n/a	Mixed	10
Schmidt et al. [24] (Sydney)	2015	Royal Prince Alfred Hospital, Australia	CR	59	Mixed	66	2	54	n/a	40	n/a	n/a	n/a	n/a	n/a	Mixed	9

CP cohort prospective, CR cohort retrospective, CC case–control, RCT randomized controlled trial, P/F ratio: PO₂/FiO₂ ratio, MV mechanical ventilation before ECMO initiation, LIS Lung Injury Score, HF hollow fibre, PP polypropylene, PMP polymethylpentene, C centrifugal, R rotatory, F-J femoro-jugular. Mean values are presented unless indicated
^aMedian values
^bNormalized coagulation ratio, see “Methods” section for explanation