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Table 1 Baseline characteristics of children treated with nasal high flow and with standard oxygen therapy for status asthmaticus

From: Nasal high flow in management of children with status asthmaticus: a retrospective observational study

  NHF n = 39 Standard oxygen n = 30 p*
Age (years), median [IQR] 3.6 [1.6–5.6] 3.6 [2.2–6.7] 0.72
Male/female ratio 20/19 21/9 0.11
Weight (kg), median [IQR] 15 [11–24] 15 [13–23] 0.64
PIM2 at admission, median [IQR] 1.5 [1.15–3.3] 1 [0.3–1.37] <0.001
History of asthma or >2 bronchiolitis, n (%) 31 (80) 23 (77) 0.79
Previous admission for asthma, n (%) 19 (48) 11 (37) 0.31
 In PICU, n (%) 4 (10) 2 (6) 0.66
Long-term control medicine, n (%) 17 (44) 14 (47) 0.80
Clinical parameters at admission, median [IQR]
 Respiratory rate (/min) 35 [31–47] 35 [30–43] 0.47
 Heart rate (/min) 164 [154–185] 168 [153–180] 0.89
 SpO2 (%) 97 [95–98] 98 [97–100] 0.04
 SpO2/FiO2 216 [175–303] NA  
Venous blood gas at admission, median [IQR]
 pH 7.35 [7.28–7.39] 7.36 [7.34–7.39] 0.27
 pCO2 (kPa) 5.6 [4.7–7.7] 4.9 [4.4–5.6] 0.02
 Bicarbonates (mmol/L) 22 [20–24] 20 [20–23] 0.35
Acidosis (pH < 7.30), n (%) 10 (26%) 2 (7%) 0.04
Associated medication, n (%)
 Salbutamol—nebulized 39 (100%) 30 (100%) 1.0
 Corticosteroids—intravenousa 31 (79%) 19 (63%) 0.14
 Salbutamol—intravenous 13 (33%) 5 (17%) 0.12
 Magnesium sulphate 23 (59%) 8 (27%) 0.007
PICU LOS (days), median [IQR] 3 [2.5–5] 1.5 [1, 2] <0.001
  1. LOS length of stay, PIM Paediatric Index of Mortality, PICU paediatric intensive care unit, NHF nasal high flow
  2. * Statistical analysis with Chi-square test for qualitative variables or Mann–Whitney U test for nonparametric independent sample
  3. aAll other children received oral corticosteroids