Matched variables
| | | | | | |
Age (years)
|
61 ± 17
|
65 ± 15
|
<0.01
|
68 ± 14
|
66 ± 15
|
0.08
|
Immunoincompetence
|
544 (21.9)
|
40 (17.9)
|
0.17
|
34 (15.9)
|
38 (17.8)
|
0.67
|
Diabetes
|
548 (21.2)
|
65 (27.8)
|
0.025
|
62 (29.0)
|
61 (28.5)
|
0.99
|
COPD
|
527 (20.4)
|
80 (34.2)
|
<0.01
|
73 (34.1)
|
72 (33.6)
|
0.99
|
Chronic renal failure
|
248 (9.6)
|
38 (16.2)
|
<0.01
|
30 (14.0)
|
33 (15.4)
|
0.75
|
Chronic cardiac failure
|
252 (9.8)
|
38 (16.2)
|
<0.01
|
38 (17.8)
|
34 (15.9)
|
0.66
|
Chronic liver failure
|
106 (4.1)
|
6 (2.6)
|
0.33
|
5 (2.3)
|
6 (2.8)
|
0.99
|
pH
|
7.33 ± 0.12
|
7.33 ± 0.12
|
0.90
|
7.33 ± 0.12
|
7.33 ± 0.12
|
0.99
|
PaO2/FiO2 ratio (mmHg)
|
159 ± 67
|
169 ± 68
|
0.03
|
169 ± 65
|
168 ± 68
|
0.86
|
Set PEEP (cmH2O)
|
8.2 ± 3.2
|
7.5 ± 2.4
|
<0.01
|
7.7 ± 2.8
|
7.5 ± 2.4
|
0.43
|
Day 1 non-pulmonary SOFA scorec
|
6.3 ± 4.1
|
5.3 ± 3.7
|
<0.01
|
5.6 ± 3.9
|
5.5 ± 3.7
|
0.70
|
NIV
|
378 (14.7)
|
58 (24.8)
|
<0.01
|
46 (21.5)
|
47 (22.0)
|
0.91
|
Outcome variables
| | | | | | |
Invasive ventilation free days to day 28 (days)
|
9 [0–21]
|
14 [0–24]
|
<0.01
|
10 [0–21]
|
14 [0–24]
|
0.16
|
Duration of invasive ventilation (days)
| | | | | | |
All patients
|
8 [4–15]
|
6 [3–14]
|
<0.01
|
8 [4–16]
|
6 [3–14]
|
<0.01
|
Surviving patients
|
9 [4–15]
|
5 [3–12]
|
<0.01
|
8 [4–16]
|
8 [4–14]
|
<0.01
|
ICU length of stay (days)
|
All patients
|
10 [5–18]
|
8 [4–16]
|
<0.01
|
11 [5–20]
|
8 [4–16]
|
0.02
|
Surviving patients
|
11 [6–20]
|
8 [4–15]
|
<0.01
|
11 [5–22]
|
8 [4–16]
|
0.02
|
Decision of withholding or withdrawing treatments
|
639 (24.8)
|
63 (26.9)
|
0.52
|
53 (24.8)
|
59 (27.6)
|
0.56
|
ICU Mortality
|
902 (35.0)
|
64 (27.3)
|
0.02
|
67 (31.3)
|
59 (27.6)
|
0.44
|
Hospital length of stay (days)
|
All patients
|
17 [8–32]
|
14 [8–26]
|
0.03
|
18 [10–32]
|
14 [8–26]
|
<0.01
|
Surviving patients
|
23 [13–40]
|
16 [11–31]
|
<0.01
|
25 [14–44]
|
16 [10–32]
|
<0.01
|
Hospital mortality
|
1029 (40.0)
|
81 (34.6)
|
0.12
|
81 (37.9)
|
75 (35.1)
|
0.60
|