Low HDL levels in sepsis versus trauma patients in intensive care unit

Tanaka, Sébastien; Labreuche, Julien; Drumez, Elodie; Harrois, Anatole; Hamada, Sophie; Vigué, Bernard; Couret, David; Duranteau, Jacques; Meilhac, Olivier

doi:10.1186/s13613-017-0284-3

Annals of Intensive Care

Table 2 Association of lipid levels with sepsis severity and short-term prognosis

From: Low HDL levels in sepsis versus trauma patients in intensive care unit

	TC		LDL-C		HDL-C		Triglycerides
	Values	P*	Values	P*	Values	P*	Values	P*
Severity variables
SOFA score at day 1²	−0.31	0.032	0.23	0.11	−0.50	0.0004	0.14	0.34
Mechanical ventilation use¹
No (n = 23)	2.03 [1.53–3.56]	0.17	0.97 [0.66–2.20]	0.29	0.52 [0.25–0.96]	0.029	1.11 [0.79–1.32]	0.45
Yes (n = 27)	1.64 [1.38–2.55]	0.17	0.88 [0.68–1.36]	0.29	0.21 [0.13–0.45]	0.029	1.25 [0.62–1.57]	0.45
Length of mechanical ventilation²	−0.20	0.17	−0.13	0.39	−0.39	0.006	0.23	0.11
Bacterial species
Gram-negative bacteria¹
No (n = 10)	2.04 [1.64–3.74]	0.55	1.11 [0.71–1.97]	0.88	0.48 [0.19–0.96]	0.53	1.37 [1.03–2.14]	0.68
Yes (n = 35)	2.03 [1.29–2.83]	0.55	0.95 [0.63–1.61]	0.88	0.30 [0.15–0.62]	0.53	1.25 [0.82–1.53]	0.68
Gram-positive cocci¹
No (n = 25)	1.81 [1.28–2.83]	0.37	0.93 [0.66–1.70]	0.83	0.21 (0.15–0.37]	0.013	1.32 [0.82–1.57]	0.57
Yes (n = 20)	2.07 [1.64–3.24]	0.37	0.97 [0.71–1.56]	0.83	0.61 [0.25–1.01]	0.013	1.24 [0.90–1.41]	0.57
Prognosis variables
Mortality in ICU¹
No (n = 40)	2.11 [1.56–3.17]	0.28	0.96 [0.70–1.66]	0.44	0.35 [0.17–0.83]	0.68	1.20 [0.81–1.56]	0.26
Yes (n = 10)	1.67 [1.26–2.11]	0.28	0.78 [0.42–1.36]	0.44	0.21 [0.17–0.55]	0.68	1.22 [0.44–1.32]	0.26
Length of stay in ICU²	−0.21	0.21	−0.31	0.055	−0.35	0.030	0.21	0.20
SOFA score >6 or died at day 3¹
No (n = 29)	2.40 [1.60–3.19]	0.003	1.03 [0.68–1.86]	0.013	0.35 [0.19–0.86]	0.033	1.25 [0.88–1.53]	0.078
Yes (n = 15)	1.53 [1.09–2.11]	0.003	0.77 [0.42–0.99]	0.013	0.20 [0.11–0.41]	0.033	0.79 [0.44-1.32]	0.078
SOFA score >6 or died at day 7¹
No (n = 15)	1.64 [1.52–2.55]	0.43	0.85 [0.67–1.03]	0.68	0.30 [0.11–0.78]	0.20	1.09 [0.79–1.57]	0.93
Yes (n = 13)	1.62 [1.28–2.11]	0.43	0.87 [0.42–1.26]	0.68	0.17 [0.12–0.37]	0.20	1.25 [0.61–1.53]	0.93

Values are medians of lipid levels reported in mmol/l [IQR] or partial Spearman’s correlation coefficient
* Age-/sex-adjusted P values (¹calculated using nonparametric ANCOVA; ²calculated using partial Spearman’s rank correlation)

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