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Table 2 Association of lipid levels with sepsis severity and short-term prognosis

From: Low HDL levels in sepsis versus trauma patients in intensive care unit

  TC LDL-C HDL-C Triglycerides
Values P* Values P* Values P* Values P*
Severity variables
SOFA score at day 12 −0.31 0.032 0.23 0.11 −0.50 0.0004 0.14 0.34
Mechanical ventilation use1
 No (n = 23) 2.03 [1.53–3.56] 0.17 0.97 [0.66–2.20] 0.29 0.52 [0.25–0.96] 0.029 1.11 [0.79–1.32] 0.45
 Yes (n = 27) 1.64 [1.38–2.55] 0.88 [0.68–1.36] 0.21 [0.13–0.45] 1.25 [0.62–1.57]
Length of mechanical ventilation2 −0.20 0.17 −0.13 0.39 −0.39 0.006 0.23 0.11
Bacterial species
Gram-negative bacteria1
 No (n = 10) 2.04 [1.64–3.74] 0.55 1.11 [0.71–1.97] 0.88 0.48 [0.19–0.96] 0.53 1.37 [1.03–2.14] 0.68
 Yes (n = 35) 2.03 [1.29–2.83] 0.95 [0.63–1.61] 0.30 [0.15–0.62] 1.25 [0.82–1.53]
Gram-positive cocci1
 No (n = 25) 1.81 [1.28–2.83] 0.37 0.93 [0.66–1.70] 0.83 0.21 (0.15–0.37] 0.013 1.32 [0.82–1.57] 0.57
 Yes (n = 20) 2.07 [1.64–3.24] 0.97 [0.71–1.56] 0.61 [0.25–1.01] 1.24 [0.90–1.41]
Prognosis variables
Mortality in ICU1
 No (n = 40) 2.11 [1.56–3.17] 0.28 0.96 [0.70–1.66] 0.44 0.35 [0.17–0.83] 0.68 1.20 [0.81–1.56] 0.26
 Yes (n = 10) 1.67 [1.26–2.11] 0.78 [0.42–1.36] 0.21 [0.17–0.55] 1.22 [0.44–1.32]
Length of stay in ICU2 −0.21 0.21 −0.31 0.055 −0.35 0.030 0.21 0.20
SOFA score >6 or died at day 31
 No (n = 29) 2.40 [1.60–3.19] 0.003 1.03 [0.68–1.86] 0.013 0.35 [0.19–0.86] 0.033 1.25 [0.88–1.53] 0.078
 Yes (n = 15) 1.53 [1.09–2.11] 0.77 [0.42–0.99] 0.20 [0.11–0.41] 0.79 [0.44-1.32]
SOFA score >6 or died at day 71
 No (n = 15) 1.64 [1.52–2.55] 0.43 0.85 [0.67–1.03] 0.68 0.30 [0.11–0.78] 0.20 1.09 [0.79–1.57] 0.93
 Yes (n = 13) 1.62 [1.28–2.11] 0.87 [0.42–1.26] 0.17 [0.12–0.37] 1.25 [0.61–1.53]
  1. Values are medians of lipid levels reported in mmol/l [IQR] or partial Spearman’s correlation coefficient
  2. * Age-/sex-adjusted P values (1calculated using nonparametric ANCOVA; 2calculated using partial Spearman’s rank correlation)