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Fig. 4 | Annals of Intensive Care

Fig. 4

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Fig. 4

Effect of HA on the production of LPS-induced circulating and pulmonary inflammatory cytokines. Pigs were allocated into LPS + HA (sham) and LPS + HA groups. Plasma was collected at baseline, and at the time point when ALI model was diagnosed (T0) and the end of the experiment schedule (8 h after T0). BALF and lung homogenates were prepared after pigs were euthanized. The systemic and pulmonary cytokine levels of IL-1β (ac), IL-6 (df), IL-8 (gi), TNF-α (jl) and IL-17A (mo) were detected by using ELISA kits. Values are mean ± SEM, N = 4 of each group. *P < 0.05; **P < 0.01; ***P < 0.001 when compared between LPS + HA (sham) and LPS + HA groups; P < 0.05 versus baseline and § P < 0.05 versus T0 when compared within each group

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