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Table 2 Systemic and pulmonary hemodynamic measurements in saline controls and LPS-challenged animals

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Parameter Group Time (h)
Baseline −3 h −2 h −1 h T0
CO (l/min) NS 4.1 ± 0.3 4.5 ± 0.4 4.1 ± 0.4 4.2 ± 0.4 4.2 ± 0.4
LPS 4.1 ± 0.3 4.1 ± 0.5 5.1 ± 0.3 5.0 ± 0.3 3.4 ± 0.3
MAP (mmHg) NS 105 ± 6 98 ± 6 102 ± 8 101 ± 7 102 ± 8
LPS 113 ± 3 78 ± 8 56 ± 4*** 57 ± 5*** 54 ± 5***
SVRI (dyn s/cm5/m2) NS 1783 ± 198 1810 ± 169 1927 ± 148 1822 ± 183 1909 ± 218
LPS 2399 ± 238 1987 ± 217 1002 ± 111** 952 ± 56** 1160 ± 97*
mPAP (mmHg) NS 16.5 ± 1.0 16.7 ± 0.5 15.7 ± 1.2 17.8 ± 1.5 18.5 ± 1.2
LPS 18.8 ± 1.5 28.8 ± 1.9*** 3.3 ± 2.0*** 34.7 ± 2.7*** 41.0 ± 1.7***
PVRI (dyn s/cm5/m2) NS 204 ± 20 193 ± 16 231 ± 48 209 ± 35 201 ± 13
LPS 364 ± 40 552 ± 115*** 542 ± 67** 634 ± 120*** 781 ± 74***
PAWP (mmHg) NS 6.0 ± 1.2 6.5 ± 1.5 6.3 ± 1.4 6.8 ± 1.5 6.8 ± 1.2
LPS 4.0 ± 1.2 5.5 ± 0.6 8.0 ± 0.6 9.0 ± 0.9 12.2 ± 1.4*
EVLWI (ml/kg) NS 9.0 ± 0.5 9.7 ± 0.9 9.3 ± 0.5 9.5 ± 0.6 10.0 ± 0.9
LPS 8.0 ± 0.5 9.7 ± 0.7 9.8 ± 0.9 11.0 ± 0.8 15.4 ± 1.3***
PVPI NS 2.7 ± 0.1 2.8 ± 0.3 3.0 ± 0.3 3.0 ± 0.3 2.9 ± 0.2
LPS 2.7 ± 0.2 3.6 ± 0.3 4.0 ± 0.7 4.6 ± 0.7 5.6 ± 0.5***
  1. Hemodynamic parameters are compared between the saline control and LPS-challenged group. (Data are mean ± SEM, N = 6 of each group; *P < 0.05, **P < 0.01, ***P < 0.001; versus control group)
  2. CO cardiac output, MAP mean arterial pressure, SVRI systemic vascular resistance index, MPAP mean pulmonary arterial pressure, PVRI pulmonary vascular resistance index, PAWP pulmonary artery wedge pressure, EVLWI extravascular lung water index, PVPI pulmonary vascular permeability index