Table 3 Variables determining oxygenation and lung mechanics in LPS + HA (sham)- and LPS + HA-treated animals
From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model
Parameter | Group | Time (h) | |||||
|---|---|---|---|---|---|---|---|
Baseline | T0 | 2 h | 4 h | 6 h | 8 h | ||
PaO2/FiO2 (mmHg) | LPS + HA (sham) | 329 ± 55 | 164 ± 10† | 131 ± 20† | 129 ± 21† | 178 ± 68 | 169 ± 53 |
LPS + HA | 387 ± 10 | 183 ± 6† | 254 ± 44* | 211 ± 31† | 264 ± 31 | 315 ± 22*§ | |
PaCO2 (mmHg) | LPS + HA (sham) | 45 ± 4 | 40 ± 7 | 45 ± 17 | 46 ± 14 | 46 ± 16 | 42 ± 14 |
LPS + HA | 37 ± 5 | 53 ± 6† | 59 ± 9† | 54 ± 3† | 51 ± 2 | 45 ± 3 | |
AaDO2 (mmHg) | LPS + HA (sham) | 96 ± 24 | 170 ± 6 | 363 ± 129 | 330 ± 103 | 371 ± 102† | 358 ± 96 |
LPS + HA | 79 ± 10 | 172 ± 29† | 368 ± 68† | 368 ± 77† | 334 ± 81† | 296 ± 66† | |
PAWPeak (mbar) | LPS + HA (sham) | 17.7 ± 1.8 | 32.0 ± 2.6† | 29.7 ± 5.2† | 29.7 ± 2.7† | 28.3 ± 1.7† | 26.7 ± 3.2 |
LPS + HA | 18.9 ± 1.5 | 29.0 ± 1.0† | 26.3 ± 1.9† | 26.3 ± 1.8† | 24.7 ± 1.8 | 24.3 ± 2.3 | |
PAWPlateau (mbar) | LPS + HA (sham) | 13.3 ± 0.9 | 21.0 ± 1.0† | 22.7 ± 2.9† | 23.3 ± 2.4† | 21.0 ± 1.0† | 21.7 ± 0.9† |
LPS + HA | 15.3 ± 1.8 | 24.7 ± 1.3† | 22.0 ± 1.2† | 21.0 ± 1.0†§ | 20.3 ± 0.9†§ | 19.0 ± 0.0*†§ | |
Resistance (mbar/l/s) | LPS + HA (sham) | 8.0 ± 1.1 | 15.0 ± 1.8 | 17.5 ± 4.6 | 13.4 ± 3.9 | 13.7 ± 3.6 | 13.3 ± 4.0 |
LPS + HA | 8.2 ± 1.0 | 11.7 ± 1.8 | 8.8 ± 1.5 | 8.7 ± 1.2 | 8.0 ± 1.1 | 7.2 ± 1.2§ | |
Compliance (ml/mbar) | LPS + HA (sham) | 32.6 ± 2.9 | 20.1 ± 6.1 | 19.6 ± 7.7 | 20.2 ± 6.0 | 20.6 ± 5.0 | 21.1 ± 5.9 |
LPS + HA | 27.1 ± 2.9 | 19 ± 2.2† | 20.1 ± 1.1 | 22.5 ± 2.0 | 22.7 ± 2.8 | 23.3 ± 2.3 | |