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Table 3 Variables determining oxygenation and lung mechanics in LPS + HA (sham)- and LPS + HA-treated animals

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Parameter Group Time (h)
Baseline T0 2 h 4 h 6 h 8 h
PaO2/FiO2 (mmHg) LPS + HA (sham) 329 ± 55 164 ± 10 131 ± 20 129 ± 21 178 ± 68 169 ± 53
LPS + HA 387 ± 10 183 ± 6 254 ± 44* 211 ± 31 264 ± 31 315 ± 22*§
PaCO2 (mmHg) LPS + HA (sham) 45 ± 4 40 ± 7 45 ± 17 46 ± 14 46 ± 16 42 ± 14
LPS + HA 37 ± 5 53 ± 6 59 ± 9 54 ± 3 51 ± 2 45 ± 3
AaDO2 (mmHg) LPS + HA (sham) 96 ± 24 170 ± 6 363 ± 129 330 ± 103 371 ± 102 358 ± 96
LPS + HA 79 ± 10 172 ± 29 368 ± 68 368 ± 77 334 ± 81 296 ± 66
PAWPeak (mbar) LPS + HA (sham) 17.7 ± 1.8 32.0 ± 2.6 29.7 ± 5.2 29.7 ± 2.7 28.3 ± 1.7 26.7 ± 3.2
LPS + HA 18.9 ± 1.5 29.0 ± 1.0 26.3 ± 1.9 26.3 ± 1.8 24.7 ± 1.8 24.3 ± 2.3
PAWPlateau (mbar) LPS + HA (sham) 13.3 ± 0.9 21.0 ± 1.0 22.7 ± 2.9 23.3 ± 2.4 21.0 ± 1.0 21.7 ± 0.9
LPS + HA 15.3 ± 1.8 24.7 ± 1.3 22.0 ± 1.2 21.0 ± 1.0†§ 20.3 ± 0.9†§ 19.0 ± 0.0*†§
Resistance (mbar/l/s) LPS + HA (sham) 8.0 ± 1.1 15.0 ± 1.8 17.5 ± 4.6 13.4 ± 3.9 13.7 ± 3.6 13.3 ± 4.0
LPS + HA 8.2 ± 1.0 11.7 ± 1.8 8.8 ± 1.5 8.7 ± 1.2 8.0 ± 1.1 7.2 ± 1.2§
Compliance (ml/mbar) LPS + HA (sham) 32.6 ± 2.9 20.1 ± 6.1 19.6 ± 7.7 20.2 ± 6.0 20.6 ± 5.0 21.1 ± 5.9
LPS + HA 27.1 ± 2.9 19 ± 2.2 20.1 ± 1.1 22.5 ± 2.0 22.7 ± 2.8 23.3 ± 2.3
  1. Oxygenation and ventilation parameters in LPS + HA (sham)- and LPS + HA-treated animals at baseline and a series of time points until the end of the experiment (data are mean ± SEM, N = 3–4 of each group; *P < 0.05 when compared between groups; P < 0.05 when compared with baseline within per group; § P < 0.05 versus T0 within per group). PaO2, oxygen partial pressure; FiO2, inspiratory oxygen fraction; PaCO2, carbon dioxide partial pressure; PAWPeak, peak airway pressure; PAWPlateau, plateau airway pressure