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Table 5 Ontology groups and associated differentially expressed plasma proteins in the time points of T0 and 8 h after HA-sham treatment versus baseline

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

GO biological process Accession Protein name Fold change over baselinea
T0/baseline 8 h/baseline
Acute-phase response/acute inflammatory response P79263 Inter-alpha-trypsin inhibitor heavy chain H4 1.22 2.17
F1SH92 Inter-alpha-trypsin inhibitor heavy chain H4 1.39 2.04
Q29056 Interleukin-1 receptor antagonist protein 1.49 1.51
F1SFI7 Alpha-2-HS-glycoprotein (Fragment) 0.76 0.49
Q29014 Alpha-1 acid glycoprotein (Fragment) 0.68 0.49
Q8SPS7 Haptoglobin 0.74 0.57
Q6S4N2 Heat shock 70 kDa protein 1B 0.64 0.65
Regulation of immune system process P01025 Complement C3 1.45 0.88
A5PF00 B-factor, properdin 0.75 0.62
F1RMN7 Hemopexin 0.70 0.63
Q69DL4 Complement C1qB (Fragment) 0.81 0.60
A0SEH0 Complement component C6 0.71 0.76
Q29041 Ficolin-2 0.75 0.69
Defense response/response to stress P52552 Peroxiredoxin-2 (Fragment) 1.28 1.30
P32195 Protegrin-2 4.76 2.43
O02705 Heat shock protein HSP 90-alpha 1.37 2.56
Q6QR67 Resistin 5.00 3.06
Proteolysis C9VZX4 Matrix metallopeptidase 1 1.79 3.98
C9VZX5 Matrix metallopeptidase 10 1.13 1.53
F2Z528 Proteasome subunit alpha type 1.22 1.22
F2Z5K2 Proteasome subunit alpha type 1.28 1.21
I3LQ51 Proteasome subunit beta type 1.49 1.50
P03974 Transitional endoplasmic reticulum ATPase 1.35 2.27
Q9GMA6 Alpha-1-antichymotrypsin 2 0.81 0.55
C4PGL9 Mannan-binding lectin serine peptidase 2 0.79 0.97
F1SCF0 Alpha-1-antitrypsin 0.81 0.66
Coagulation F1RPW2 Coagulation factor V 0.66 0.45
F1RZ36 Coagulation factor VIII 0.64 0.74
O97507 Coagulation factor XII 0.76 0.66
K7GQL2 Coagulation factor XIII, A1 polypeptide 0.71 0.79
F1RX36 Fibrinogen alpha chain 0.83 1.11
P14460 Fibrinogen alpha chain (Fragment) 1.47 3.12
P14477 Fibrinogen beta chain (fragment) 1.39 2.30
P06867 Plasminogen 0.77 0.57
F1SB81 Plasminogen 0.59 0.59
B3STX9 Prothrombin 0.68 0.76
Negative regulation of blood coagulation I3LRJ4 Vitamin K-dependent protein C 0.69 0.57
Metabolic process Q29214 60S acidic ribosomal protein P0 1.47 2.45
F1RYZ0 60S acidic ribosomal protein P2 2.17 4.72
P01965 Hemoglobin subunit alpha 1.39 0.68
F1RII7 Hemoglobin subunit beta 1.28 0.74
A0SNU7 Glyceraldehyde-3-phosphate dehydrogenase (fragment) 1.23 1.41
G9F6X8 Prolyl 4-hydroxylase beta polypeptide 1.45 2.14
F1SN27 Sorbitol dehydrogenase 1.67 3.13
Regulation of lipid storage Q2LE37 Apolipoprotein M 1.25 1.02
Q29248 Apolipoprotein A-I (Fragment) 0.79 0.79
Cellular metal ion homeostasis Q8WMN8 Lactoferrin (Fragment) 1.64 0.93
P09571 Serotransferrin 0.77 0.63
Transport P04404 Chromogranin-A (Fragment) 1.75 1.89
Q29545 Inhibitor of carbonic anhydrase 0.67 0.54
A4US67 Paraoxonase 0.75 0.67
F1RUN2 Serum albumin 0.76 0.60
P50390 Transthyretin 0.81 0.76
Positive regulation of cell differentiation Q0PM28 Pigment epithelium-derived factor 0.70 0.84
Multicellular organismal process P00761 Trypsin 0.78 0.55
Response to unfolded protein F1RS36 78 kDa glucose-regulated protein 1.33 1.38
Cytoskeleton organization I3LVD5 Actin, cytoplasmic 1 1.64 1.09
A0A0B8RSX6 Filamin A, alpha 1.45 1.71
B6VNT8 Cardiac muscle alpha actin 1 1.82 1.39
Q6QA25 Tropomyosin 3 1.59 1.91
P67937 Tropomyosin alpha-4 chain 1.23 1.29
Q767L7 Tubulin beta chain 1.37 0.84
P02543 Vimentin 1.54 5.13
Obsolete GTP catabolic process Q0PY11 Elongation factor 1-alpha 1.35 1.37
Chromosome organization P62802 Histone H4 2.50 1.87
Tissue remodeling Q711S8 Secreted phosphoprotein 24 0.82 0.79
Regulation of biological process F1S682 Sulfhydryl oxidase 0.80 0.86
  1. aNote that changes are expressed as relative abundance of the plasma proteins at T0 or 8 h after HA-sham treatment compared with baseline within the LPS + HA (sham) group. A fold change ≥ 1.20, p < 0.05 represents more protein abundance in T0 or 8 h versus baseline. By contrast, a fold change ≤ 0.83, p < 0.05 represents less protein abundance in T0 or 8 h versus baseline