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Table 5 Ontology groups and associated differentially expressed plasma proteins in the time points of T0 and 8 h after HA-sham treatment versus baseline

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

GO biological process

Accession

Protein name

Fold change over baselinea

T0/baseline

8 h/baseline

Acute-phase response/acute inflammatory response

P79263

Inter-alpha-trypsin inhibitor heavy chain H4

1.22

2.17

F1SH92

Inter-alpha-trypsin inhibitor heavy chain H4

1.39

2.04

Q29056

Interleukin-1 receptor antagonist protein

1.49

1.51

F1SFI7

Alpha-2-HS-glycoprotein (Fragment)

0.76

0.49

Q29014

Alpha-1 acid glycoprotein (Fragment)

0.68

0.49

Q8SPS7

Haptoglobin

0.74

0.57

Q6S4N2

Heat shock 70 kDa protein 1B

0.64

0.65

Regulation of immune system process

P01025

Complement C3

1.45

0.88

A5PF00

B-factor, properdin

0.75

0.62

F1RMN7

Hemopexin

0.70

0.63

Q69DL4

Complement C1qB (Fragment)

0.81

0.60

A0SEH0

Complement component C6

0.71

0.76

Q29041

Ficolin-2

0.75

0.69

Defense response/response to stress

P52552

Peroxiredoxin-2 (Fragment)

1.28

1.30

P32195

Protegrin-2

4.76

2.43

O02705

Heat shock protein HSP 90-alpha

1.37

2.56

Q6QR67

Resistin

5.00

3.06

Proteolysis

C9VZX4

Matrix metallopeptidase 1

1.79

3.98

C9VZX5

Matrix metallopeptidase 10

1.13

1.53

F2Z528

Proteasome subunit alpha type

1.22

1.22

F2Z5K2

Proteasome subunit alpha type

1.28

1.21

I3LQ51

Proteasome subunit beta type

1.49

1.50

P03974

Transitional endoplasmic reticulum ATPase

1.35

2.27

Q9GMA6

Alpha-1-antichymotrypsin 2

0.81

0.55

C4PGL9

Mannan-binding lectin serine peptidase 2

0.79

0.97

F1SCF0

Alpha-1-antitrypsin

0.81

0.66

Coagulation

F1RPW2

Coagulation factor V

0.66

0.45

F1RZ36

Coagulation factor VIII

0.64

0.74

O97507

Coagulation factor XII

0.76

0.66

K7GQL2

Coagulation factor XIII, A1 polypeptide

0.71

0.79

F1RX36

Fibrinogen alpha chain

0.83

1.11

P14460

Fibrinogen alpha chain (Fragment)

1.47

3.12

P14477

Fibrinogen beta chain (fragment)

1.39

2.30

P06867

Plasminogen

0.77

0.57

F1SB81

Plasminogen

0.59

0.59

B3STX9

Prothrombin

0.68

0.76

Negative regulation of blood coagulation

I3LRJ4

Vitamin K-dependent protein C

0.69

0.57

Metabolic process

Q29214

60S acidic ribosomal protein P0

1.47

2.45

F1RYZ0

60S acidic ribosomal protein P2

2.17

4.72

P01965

Hemoglobin subunit alpha

1.39

0.68

F1RII7

Hemoglobin subunit beta

1.28

0.74

A0SNU7

Glyceraldehyde-3-phosphate dehydrogenase (fragment)

1.23

1.41

G9F6X8

Prolyl 4-hydroxylase beta polypeptide

1.45

2.14

F1SN27

Sorbitol dehydrogenase

1.67

3.13

Regulation of lipid storage

Q2LE37

Apolipoprotein M

1.25

1.02

Q29248

Apolipoprotein A-I (Fragment)

0.79

0.79

Cellular metal ion homeostasis

Q8WMN8

Lactoferrin (Fragment)

1.64

0.93

P09571

Serotransferrin

0.77

0.63

Transport

P04404

Chromogranin-A (Fragment)

1.75

1.89

Q29545

Inhibitor of carbonic anhydrase

0.67

0.54

A4US67

Paraoxonase

0.75

0.67

F1RUN2

Serum albumin

0.76

0.60

P50390

Transthyretin

0.81

0.76

Positive regulation of cell differentiation

Q0PM28

Pigment epithelium-derived factor

0.70

0.84

Multicellular organismal process

P00761

Trypsin

0.78

0.55

Response to unfolded protein

F1RS36

78 kDa glucose-regulated protein

1.33

1.38

Cytoskeleton organization

I3LVD5

Actin, cytoplasmic 1

1.64

1.09

A0A0B8RSX6

Filamin A, alpha

1.45

1.71

B6VNT8

Cardiac muscle alpha actin 1

1.82

1.39

Q6QA25

Tropomyosin 3

1.59

1.91

P67937

Tropomyosin alpha-4 chain

1.23

1.29

Q767L7

Tubulin beta chain

1.37

0.84

P02543

Vimentin

1.54

5.13

Obsolete GTP catabolic process

Q0PY11

Elongation factor 1-alpha

1.35

1.37

Chromosome organization

P62802

Histone H4

2.50

1.87

Tissue remodeling

Q711S8

Secreted phosphoprotein 24

0.82

0.79

Regulation of biological process

F1S682

Sulfhydryl oxidase

0.80

0.86

  1. aNote that changes are expressed as relative abundance of the plasma proteins at T0 or 8 h after HA-sham treatment compared with baseline within the LPS + HA (sham) group. A fold change ≥ 1.20, p < 0.05 represents more protein abundance in T0 or 8 h versus baseline. By contrast, a fold change ≤ 0.83, p < 0.05 represents less protein abundance in T0 or 8 h versus baseline