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Annals of Intensive Care

Table 6 Ontology groups and associated differentially expressed plasma proteins in the time points of T0 and 8 h after HA treatment versus baseline

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

GO biological process

Accession

Protein name

Fold change over baselinea

T0/baseline

8 h/baseline

Acute-phase response/acute inflammatory response

Q29014

Alpha-1 acid glycoprotein (Fragment)

2.70

0.87

K9J6H8

Alpha-2-macroglobulin

1.82

1.01

I3L6K3

C-reactive protein

1.43

2.50

F1RJ76

C-reactive protein

1.27

1.32

Q8SPS7

Haptoglobin

2.08

1.00

P79263

Inter-alpha-trypsin inhibitor heavy chain H4

1.89

1.78

F1SH92

Inter-alpha-trypsin inhibitor heavy chain H4

1.47

1.19

Q29056

Interleukin-1 receptor antagonist protein

2.44

1.44

F1S9B8

Serum amyloid A protein

1.64

1.35

Regulation of immune system process

P01025

Complement C3

1.50

1.34

F1SMJ1

Complement component C7 (Fragment)

1.23

1.07

A5PF00

B-factor, properdin

2.50

0.95

F1RMN7

Hemopexin

1.85

1.08

L8B0S2

IgG heavy chain

1.82

1.00

L8B0W9

IgG heavy chain

1.30

0.94

K7ZPU8

IgG heavy chain constant region (Fragment)

1.59

0.72

Q4Z8N7

Plasma platelet-activating factor acetylhydrolase

1.20

1.38

P28491

Calreticulin

0.81

1.29

B0LUW3

Chemerin

0.62

0.79

F1STZ4

Complement C1q subcomponent subunit A

0.83

0.82

Q29041

Ficolin-2

0.77

0.72

A5A758

Keratin 1 (Fragment)

0.53

0.69

C4PGL9

Mannan-binding lectin serine peptidase 2

0.65

0.75

Defense response/response to stress

A2SW51

Monocyte differentiation antigen CD14

1.64

1.60

P52552

Peroxiredoxin-2 (Fragment)

1.59

1.64

P32195

Protegrin-2

1.25

1.05

B3STX9

Prothrombin

1.28

1.01

F5XVC2

von Willebrand factor

1.35

1.07

Q6QR67

Resistin

1.79

1.52

Proteolysis

Q9GMA6

Alpha-1-antichymotrypsin 2

1.47

1.03

F1SCF0

Alpha-1-antitrypsin

2.04

0.87

C9VZX4

Matrix metallopeptidase 1

1.47

1.22

C9VZX5

Matrix metallopeptidase 10

1.43

1.21

Coagulation

P14460

Fibrinogen alpha chain (Fragment)

1.54

3.30

P14477

Fibrinogen beta chain (Fragment)

1.43

1.78

F1RQ75

Coagulation factor IX

0.78

0.60

F1RPW2

Coagulation factor V

0.79

0.67

Q19AZ7

Coagulation factor VII isoform b protein

0.72

0.81

K7GQL2

Coagulation factor XIII, A1 polypeptide

0.51

0.54

Negative regulation of blood coagulation

I3LRJ4

Vitamin K-dependent protein C

0.74

0.64

Metabolic process

F1S1G8

Amine oxidase

1.64

1.01

P01965

Hemoglobin subunit alpha

2.17

1.11

F1RII7

Hemoglobin subunit beta

1.89

1.22

Q29052

Inter-alpha-trypsin inhibitor heavy chain H1

1.32

1.08

F8SIP2

EGF-containing fibulin-like extracellular matrix protein 1

0.80

1.09

O02668

Inter-alpha-trypsin inhibitor heavy chain H2

0.74

0.64

I3LL80

L-lactate dehydrogenase

0.81

0.65

Q29126

Protein WAP-3

0.31

0.84

Regulation of lipid storage

A0A0F6TNY5

APOB O

1.43

1.09

Q29433

Apolipoprotein B (Fragment)

2.17

1.21

Q2LE37

Apolipoprotein M

1.23

1.04

O97674

Lipoprotein lipase (Fragment)

0.62

0.64

D3Y264

Apolipoprotein C-II

0.80

0.63

F1RM45

Apolipoprotein E

0.75

0.89

Q03472

Apolipoprotein R

0.72

0.60

Q8WMN7

Plasma phospholipid transfer protein

0.79

0.85

Cellular metal ion homeostasis

I3VKE6

Ceruloplasmin

1.30

1.07

Q6YT39

Lactotransferrin

1.61

1.33

P09571

Serotransferrin

2.33

0.91

D7RK08

Transferrin receptor protein

1.45

1.30

Transport

F1RUN2

Serum albumin

2.08

1.01

P50390

Transthyretin

1.33

0.89

Positive regulation of cell differentiation

Q0PM28

Pigment epithelium-derived factor

1.32

1.11

Multicellular organismal process

Q711S8

Secreted phosphoprotein 24

0.74

0.72

O11780

Transforming growth factor-beta-induced protein ig-h3

0.83

0.97

P67937

Tropomyosin alpha-4 chain

0.81

1.23

P00761

Trypsin

0.82

0.85

  1. aNote that changes are expressed as relative abundance of the plasma proteins at T0 or 8 h after HA treatment compared with baseline within the LPS + HA group. A fold change ≥1.20, P < 0.05 represents more protein abundance in T0 or 8 h versus baseline. By contrast, a fold change ≤0.83, P < 0.05 represents less protein abundance in T0 or 8 h versus baseline
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