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Table 6 Ontology groups and associated differentially expressed plasma proteins in the time points of T0 and 8 h after HA treatment versus baseline

From: Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

GO biological process Accession Protein name Fold change over baselinea
T0/baseline 8 h/baseline
Acute-phase response/acute inflammatory response Q29014 Alpha-1 acid glycoprotein (Fragment) 2.70 0.87
K9J6H8 Alpha-2-macroglobulin 1.82 1.01
I3L6K3 C-reactive protein 1.43 2.50
F1RJ76 C-reactive protein 1.27 1.32
Q8SPS7 Haptoglobin 2.08 1.00
P79263 Inter-alpha-trypsin inhibitor heavy chain H4 1.89 1.78
F1SH92 Inter-alpha-trypsin inhibitor heavy chain H4 1.47 1.19
Q29056 Interleukin-1 receptor antagonist protein 2.44 1.44
F1S9B8 Serum amyloid A protein 1.64 1.35
Regulation of immune system process P01025 Complement C3 1.50 1.34
F1SMJ1 Complement component C7 (Fragment) 1.23 1.07
A5PF00 B-factor, properdin 2.50 0.95
F1RMN7 Hemopexin 1.85 1.08
L8B0S2 IgG heavy chain 1.82 1.00
L8B0W9 IgG heavy chain 1.30 0.94
K7ZPU8 IgG heavy chain constant region (Fragment) 1.59 0.72
Q4Z8N7 Plasma platelet-activating factor acetylhydrolase 1.20 1.38
P28491 Calreticulin 0.81 1.29
B0LUW3 Chemerin 0.62 0.79
F1STZ4 Complement C1q subcomponent subunit A 0.83 0.82
Q29041 Ficolin-2 0.77 0.72
A5A758 Keratin 1 (Fragment) 0.53 0.69
C4PGL9 Mannan-binding lectin serine peptidase 2 0.65 0.75
Defense response/response to stress A2SW51 Monocyte differentiation antigen CD14 1.64 1.60
P52552 Peroxiredoxin-2 (Fragment) 1.59 1.64
P32195 Protegrin-2 1.25 1.05
B3STX9 Prothrombin 1.28 1.01
F5XVC2 von Willebrand factor 1.35 1.07
Q6QR67 Resistin 1.79 1.52
Proteolysis Q9GMA6 Alpha-1-antichymotrypsin 2 1.47 1.03
F1SCF0 Alpha-1-antitrypsin 2.04 0.87
C9VZX4 Matrix metallopeptidase 1 1.47 1.22
C9VZX5 Matrix metallopeptidase 10 1.43 1.21
Coagulation P14460 Fibrinogen alpha chain (Fragment) 1.54 3.30
P14477 Fibrinogen beta chain (Fragment) 1.43 1.78
F1RQ75 Coagulation factor IX 0.78 0.60
F1RPW2 Coagulation factor V 0.79 0.67
Q19AZ7 Coagulation factor VII isoform b protein 0.72 0.81
K7GQL2 Coagulation factor XIII, A1 polypeptide 0.51 0.54
Negative regulation of blood coagulation I3LRJ4 Vitamin K-dependent protein C 0.74 0.64
Metabolic process F1S1G8 Amine oxidase 1.64 1.01
P01965 Hemoglobin subunit alpha 2.17 1.11
F1RII7 Hemoglobin subunit beta 1.89 1.22
Q29052 Inter-alpha-trypsin inhibitor heavy chain H1 1.32 1.08
F8SIP2 EGF-containing fibulin-like extracellular matrix protein 1 0.80 1.09
O02668 Inter-alpha-trypsin inhibitor heavy chain H2 0.74 0.64
I3LL80 L-lactate dehydrogenase 0.81 0.65
Q29126 Protein WAP-3 0.31 0.84
Regulation of lipid storage A0A0F6TNY5 APOB O 1.43 1.09
Q29433 Apolipoprotein B (Fragment) 2.17 1.21
Q2LE37 Apolipoprotein M 1.23 1.04
O97674 Lipoprotein lipase (Fragment) 0.62 0.64
D3Y264 Apolipoprotein C-II 0.80 0.63
F1RM45 Apolipoprotein E 0.75 0.89
Q03472 Apolipoprotein R 0.72 0.60
Q8WMN7 Plasma phospholipid transfer protein 0.79 0.85
Cellular metal ion homeostasis I3VKE6 Ceruloplasmin 1.30 1.07
Q6YT39 Lactotransferrin 1.61 1.33
P09571 Serotransferrin 2.33 0.91
D7RK08 Transferrin receptor protein 1.45 1.30
Transport F1RUN2 Serum albumin 2.08 1.01
P50390 Transthyretin 1.33 0.89
Positive regulation of cell differentiation Q0PM28 Pigment epithelium-derived factor 1.32 1.11
Multicellular organismal process Q711S8 Secreted phosphoprotein 24 0.74 0.72
O11780 Transforming growth factor-beta-induced protein ig-h3 0.83 0.97
P67937 Tropomyosin alpha-4 chain 0.81 1.23
P00761 Trypsin 0.82 0.85
  1. aNote that changes are expressed as relative abundance of the plasma proteins at T0 or 8 h after HA treatment compared with baseline within the LPS + HA group. A fold change ≥1.20, P < 0.05 represents more protein abundance in T0 or 8 h versus baseline. By contrast, a fold change ≤0.83, P < 0.05 represents less protein abundance in T0 or 8 h versus baseline