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Table 2 Patients’ characteristics

From: Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study

Variables All patients Non-brain-injured patients Brain-injured patients p value
Number of patients 86 49 (57) 37 (43)  
Women—n (%) 29 (34) 15 (31) 14 (38) 0.50
Age (years)—mean ± SD 61 ± 19 63 ± 16 58 ± 21 0.21
SAPS II at admission—median (IQR) 48 (36 to 61) 45 (30 to 61) 50 (41 to 58) 0.45
At the time of inclusion
 Sepsis—n (%) 56 (65) 46 (94) 10 (27) <0.0001
RASS −5 (−5 to −4) −5 (−5 to −4) −5 (−5 to −5) 0.82
Use of sedation—n (%)     <0.0001
 Synchronization with ventilator 44 (51) 33(67) 11 (30)  
 Intracranial hypertension 16 (19) 0 (0) 16 (43)  
 Others 26 (30) 16 (33) 10 (27)  
Sedative drug used
 Midazolam—n (%) 79 (92) 48 (98) 31 (84) 0.02
 Sufentanyl—n (%) 79 (92) 47 (96) 32 (86) 0.40
 Propofol—n (%) 9 (10) 3 (6) 6 (16) 0.13
Total day-3 SOFA—median (IQR) 11 (8 to 14) 13 (10 to 15) 10 (8 to 11) 0.0006
Non-neurological day-3 SOFA—median (IQR) 7 (5 to 10) 9 (6 to 11) 6 (4 to 7) 0.052
Renal day-3 SOFA—median (IQR) 0 (0 to 2) 1 (0 to 3) 0 (0 to 1) 0.03
Liver day-3 SOFA—median (IQR) 0 (0 to 1) 0 (0 to 1) 0 (0 to 0) 0.19
Outcomes
 Duration of sedation (days)—median (IQR) 7 (4 to 14) 7 (5 to 14) 8 (4 to 12) 0.48
 Duration of mechanical ventilation (days)—median (IQR) 15 (7 to 30) 10 (6 to 34) 18 (10 to 27) 0.15
 Delirium—n (%) 35/61 (57) 17/30 (57) 18/31 (58) >0.99
 Delayed awakening—n (%) 23/63 (37) 7/32 (22) 16/31 (52) 0.02
 Altered mental status—n (%) 49/63 (78) 21/31 (68) 28/32 (88) 0.07
 In-ICU mortality—n (%) 37/86 (43) 24/49 (49) 13/37 (35) 0.19
  1. SAPS II Simplified Acute Physiology Score, EP evoked potentials, EEG electroencephalogram, SIRS Systemic Inflammatory Response Syndrome, RASS Richmond Assessment Sedation Scale, SOFA Sepsis-related organ failure assessment, ICU intensive care unit, delirium was defined according to the CAM-ICU