|
Number of patients
|
86
|
49 (57)
|
37 (43)
| |
|
Women—n (%)
|
29 (34)
|
15 (31)
|
14 (38)
|
0.50
|
|
Age (years)—mean ± SD
|
61 ± 19
|
63 ± 16
|
58 ± 21
|
0.21
|
|
SAPS II at admission—median (IQR)
|
48 (36 to 61)
|
45 (30 to 61)
|
50 (41 to 58)
|
0.45
|
|
At the time of inclusion
|
|
Sepsis—n (%)
|
56 (65)
|
46 (94)
|
10 (27)
|
<0.0001
|
|
RASS
|
−5 (−5 to −4)
|
−5 (−5 to −4)
|
−5 (−5 to −5)
|
0.82
|
|
Use of sedation—n (%)
| | | |
<0.0001
|
|
Synchronization with ventilator
|
44 (51)
|
33(67)
|
11 (30)
| |
|
Intracranial hypertension
|
16 (19)
|
0 (0)
|
16 (43)
| |
|
Others
|
26 (30)
|
16 (33)
|
10 (27)
| |
|
Sedative drug used
|
|
Midazolam—n (%)
|
79 (92)
|
48 (98)
|
31 (84)
|
0.02
|
|
Sufentanyl—n (%)
|
79 (92)
|
47 (96)
|
32 (86)
|
0.40
|
|
Propofol—n (%)
|
9 (10)
|
3 (6)
|
6 (16)
|
0.13
|
|
Total day-3 SOFA—median (IQR)
|
11 (8 to 14)
|
13 (10 to 15)
|
10 (8 to 11)
|
0.0006
|
|
Non-neurological day-3 SOFA—median (IQR)
|
7 (5 to 10)
|
9 (6 to 11)
|
6 (4 to 7)
|
0.052
|
|
Renal day-3 SOFA—median (IQR)
|
0 (0 to 2)
|
1 (0 to 3)
|
0 (0 to 1)
|
0.03
|
|
Liver day-3 SOFA—median (IQR)
|
0 (0 to 1)
|
0 (0 to 1)
|
0 (0 to 0)
|
0.19
|
|
Outcomes
|
|
Duration of sedation (days)—median (IQR)
|
7 (4 to 14)
|
7 (5 to 14)
|
8 (4 to 12)
|
0.48
|
|
Duration of mechanical ventilation (days)—median (IQR)
|
15 (7 to 30)
|
10 (6 to 34)
|
18 (10 to 27)
|
0.15
|
|
Delirium—n (%)
|
35/61 (57)
|
17/30 (57)
|
18/31 (58)
|
>0.99
|
|
Delayed awakening—n (%)
|
23/63 (37)
|
7/32 (22)
|
16/31 (52)
|
0.02
|
|
Altered mental status—n (%)
|
49/63 (78)
|
21/31 (68)
|
28/32 (88)
|
0.07
|
|
In-ICU mortality—n (%)
|
37/86 (43)
|
24/49 (49)
|
13/37 (35)
|
0.19
|
