|
Variables
|
Survivors
|
Non-survivors
|
p value
|
No altered mental status
|
Altered mental status
|
p value
|
|---|
|
Number of patients—n (%)
|
49 (57)
|
37 (43)
| |
14 (22)
|
49 (78)
| |
|
Age (years)—mean (SD)
|
58 (18)
|
64 (19)
|
0.058
|
58 (20)
|
60 (20)
|
0.75
|
|
Women—n (%)
|
19 (39)
|
10 (27)
|
0.36
|
5 (36)
|
20 (41)
|
>0.99
|
|
SAPS II—median (IQR)
|
48 (37 to 60)
|
53 (34 to 70)
|
0.47
|
45 (28 to 53)
|
48 (37 to 59)
|
0.36
|
|
Day-3 SOFA—median (IQR)
|
10 (8 to 12)
|
13 (10 to 17)
|
0.004
|
10 (8 to 12)
|
10 (8 to 13)
|
0.96
|
|
GCS—median (IQR)
|
3 (3 to 4)
|
3 (3 to 3)
|
0.18
|
3 (3 to 3)
|
3 (3 to 5)
|
0.29
|
|
FOUR Score—median (IQR)
|
4 (3 to 6.5)
|
4 (0 to 4.0)
|
0.026
|
4 (3.2 to 5)
|
4 (3 to 7)
|
0.85
|
|
Abolition of cough reflex-n (%)
|
7 (15)
|
17 (47)
|
0.003
|
3 (21)
|
10 (22)
|
>0.99
|
|
RASSa—median (IQR)
|
−5 (−5 to −4)
|
−5 (−5 to −5)
|
0.001
|
−5 (−5 to −4)
|
−5 (−5 to −4)
|
0.95
|
|
Brain injured—n (%)
|
24 (49)
|
13 (35)
|
0.27
|
4 (29)
|
28 (57)
|
0.07
|
|
Sedative drug used
|
|
Midazolam—n (%)
|
44 (90)
|
35 (95)
|
0.43
|
13 (93)
|
44 (90)
|
>0.99
|
|
Sufentanil—n (%)
|
44 (90)
|
35 (95)
|
0.86
|
13 (93)
|
44 (90)
|
>0.99
|
|
Propofol—n (%)
|
9 (18)
|
0 (0)
|
0.009
|
0 (0)
|
8 (16)
|
0.18
|
|
Conduction times (ms)—mean (SD)
|
|
SSEP N9–N13 IPL
|
3.8 (0.9)
|
4 (0.9)
|
0.17
|
3.7 (0.6)
|
3.9 (0.9)
|
>0.99
|
|
SSEP P14–N20 IPL (ICCT)a
|
5.2 (1.6)
|
5.6 (1.5)
|
0.02
|
5.1 (1.3)
|
5.4 (1.6)
|
0.64
|
|
BAEP I–III IPL
|
2.2 (0.3)
|
2.4 (0.3)
|
0.09
|
2.3 (0.3)
|
2.3 (0.3)
|
0.81
|
|
BAEP III–V IPL (IPCT)
|
2.2 (0.5)
|
2.3 (0.4)
|
0.33
|
2.0 (0.3)
|
2.3 (0.5)
|
0.001
|
|
Delayed conduction time—n (%)
|
|
SSEP N9–N13 IPL
|
7 (14)
|
7 (19)
|
0.57
|
1 (7)
|
6 (12)
|
>0.99
|
|
SSEP P14–N20 IPL
|
17 (35)
|
22 (59)
|
0.029
|
5 (36)
|
22 (45)
|
0.76
|
|
BAEP I–III IPL
|
9 (18)
|
8 (22)
|
0.79
|
3 (21)
|
7 (14)
|
0.68
|
|
BAEP III–V IPL
|
8 (16)
|
7 (19)
|
0.78
|
0 (0)
|
12 (24)
|
0.053
|
-
IPL inter-peak latency. ICCT intracranial conduction time, IPCT intra- pontine conduction time; IPL of SSEP or BAEP’s components were scored as “delayed” when they were greater than the “mean + 2.5 SD” of the ones of a healthy control group
-
aN20 was abolished in three patients. P14–N20 IPL were consequently considered as delayed for these three patients with abolished N20
