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Table 1 Characteristics of patients without and with red blood cell transfusions at day 1/2

From: Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies

Characteristics No RBC transfusion (n = 421) RBC transfusion (n = 210) p
Demographics
 Age (years) 60 [49–71] 60 [49–69] 0.68
 Male gender 268 (63.7%) 138 (65.7%) 0.30
Comorbid illnesses
 Performance status 3–4 87 (20.7%) 51 (24.3%) 0.35
 Charlson comorbidity index 4 [3–6] 4 [2–5] 0.77
 Cardiovascular comorbidity 155 (36.8%) 77 (36.7%) 1
  Coronary disease 31 (7.3%) 19 (9.0%) 0.53
  Chronic heart failure 20 (4.8%) 14 (6.7%) 0.35
  Peripheral arterial disease 19 (4.5%) 6 (2.8%) 0.39
Underlying malignancy    0.01
 Non-Hodgkin lymphoma 149 (35.4%) 53 (25.2%)  
 Hodgkin lymphoma 13 (3.1%) 2 (1.0%)  
 Chronic lymphocytic leukemia 37 (8.8%) 13 (6.2%)  
 Acute lymphocytic leukemia 23 (5.5%) 20 (9.5%)  
 Acute myeloid leukemia 88 (20.9%) 69 (32.3%)  
 Chronic myeloid leukemia 8 (1.9%) 4 (1.9%)  
 Myeloma 56 (13.3%) 26 (12.4%)  
 Myelodysplastic syndrome 23 (5.5%) 12 (5.7%)  
 Others 24 (5.7%) 11 (5.2%)  
Time between diagnosis and ICU admission (days) 294 [38–1309] 199 [29–817] 0.06
Hematopoietic stem cell transplantation
 Autologous 50 (11.9%) 26 (12.4%) 0.72
 Allogeneic 77 (18.3%) 33 (15.7%) 0.49
Malignancy status    
 Newly diagnosed 120 (28.6%) 70 (33.3%) 0.95
 Partial/complete remission 115 (27.5%) 54 (25.7%) 0.54
Time between hospital and ICU admissions (days) 6 [1–21] 8 [1–19] 0.38
ICU admission characteristics
 SOFA 6 [4–9] 8 [5–11] <0.001
 Hemoglobin (g/dL) 9.7 [8.7–11] 7.8 [7.1–8.8] <0.001
 Hemoglobin ranges [n (%)]    0.001
  >9 g/dL 259 (66.1%) 44 (21.9%)  
  7–9 g/dL 126 (32.1%) 117 (58.2%)  
  <7 g/dL 7 (1.8%) 40 (19.9%)  
 Platelet count (G/L) 77 [32–170] 31 [16–63] <0.001
 Neutropenia 122 (29.0%) 107 (51.0%) <0.001
 Lactate level (mmol/L) 2.0 [1.2–3.7] 2.3 [1.5–4.9] 0.02
Source of infection
 Pneumonia 252 (59.9%) 106 (50.5%) 0.03
 Abdominal 15.7% 17.6% 0.61
 Urinary tract 26 (6.2%) 10 (4.8%) 0.59
 Catheter-related 5.0% 3.3% 0.46
Pathogens
 Gram-negative bacteria 108 (25.7%) 67 (31.9%) 0.12
 Gram-positive bacteria 60 (14.3%) 21 (10.0%) 0.69
 Aspergillus 46 (10.9%) 23 (11.0%) 1.00
 Pneumocystis 20 (4.8%) 2 (1.0%) 0.02
Life-supporting interventions
 Vasopressive drugs 243 (57.7%) 147 (70%) 0.004
 Invasive ventilation 205 (48.7%) 116 (55.2%) 0.01
 Renal replacement therapy 92 (22.2%) 62 (30.5%) 0.03
Platelet transfusions
 Day 1 70 (16.6%) 96 (45.7%) <0.001
 Day 2 58 (13.7%) 82 (39.0%) <0.001
Mortality
 ICU mortality 106 (25.2%) 82 (39.0%) <0.001
 Hospital mortality 154 (36.6%) 107 (51.0%) <0.001
  1. ICU intensive care unit, RBC red blood cell, SOFA sequential organ failure assessment