Table 3 Main characteristics of the study population for ESBL acquisition and factors associated with ESBL acquisition in univariate analysis
Variable | All patients n = 221 | No ESBL acquisition n = 212 | ESBL acquisition n = 9 | p |
|---|---|---|---|---|
Age (years) | 67.0 [55.0, 77.0] | 66.5 [55.0, 76.0] | 82.0 [66.0, 82.0] | 0.07 |
Age > 65 years | 123 (55.6) | 116 (54.7) | 7 (78) | 0.3 |
Male gender | 144 (65.2) | 137 (64.6) | 7 (77.8) | 0.5 |
SAPS II | 49.0 [35.0, 66.0] | 48.0 [35.0, 65.0] | 72.0 [55.0, 77.0] | 0.007 |
SOFA score | 7.0 [4.0, 10.0] | 7.0 [4.0, 10.0] | 10.0 [9.0, 12.0] | 0.01 |
Preexisting condition | ||||
Heart failure | 32 (14.5) | 30 (14.1) | 2 (28.6) | 0.6 |
Peripheral arterial disease | 25 (11.3) | 22 (10.3) | 3 (33.3) | 0.07 |
Diabetes | 54 (24.4) | 51 (24) | 3 (33.3) | 0.5 |
Cirrhosis | 10 (4.5) | 9 (4.2) | 1 (11.1) | 0.4 |
Chronic obstructive pulmonary disease | 39 (17.6) | 37 (17.5) | 2 (22.2) | 0.7 |
Chronic kidney disease | 36 (16.3) | 32 (15.1) | 4 (44.4) | 0.04 |
Immunosuppression | 38 (17.2) | 36 (17.0) | 2 (22.2) | 0.7 |
Mechanical ventilation | 166 (75.1) | 157 (74.1) | 9 (100) | 0.1 |
Catecholamine use | 132 (59.7) | 123 (58.0) | 9 (100) | 0.01 |
Duration of mechanical ventilation (days) | 4.0 [1.0, 10.0] | 4.0 [0.0, 10.0] | 9.0 [7.0, 11.0] | 0.03 |
ICU length of stay (days) | 8.0 [5.0, 12.0] | 7.0 [5.0, 12.0] | 11.0 [9.0, 26.0] | 0.007 |
Transfer from another unit | 124 (56.1) | 117 (55.2) | 7 (77.8) | 0.3 |
Postoperative care | 58 (26.2) | 54 (25.5) | 4 (44.4) | 0.2 |
Hospitalization within the previous 3 months | 123 (55.7) | 117 (55.2) | 6 (66.7) | 0.7 |
Antibiotics within the previous 3 months | 40 (18.1) | 37 (17.5) | 3 (33.3) | 0.2 |
Antibiotics during ICU stay | 193 (87.3) | 184 (86.8) | 9 (100) | 0.6 |
Duration of antibiotic therapy | 5.0 [3.0, 8.0] | 5.0 [3.0, 8.0] | 8.0 [5.0, 13.5] | 0.1 |