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Table 2 Colistin ELF and plasma concentrations after nebulization with different doses

From: Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care

Study

Athanassa [44] (n = 20)a

Boisson [45] (n = 12)a

Bihan [46] (n = 1)b

Lu [6] (n = 16)b

Nebulized dose

1 MIU

2 MIU

4 MIU

5 MIU

Nebulizer

Vibrating mesh nebulizer, continuous delivery, optimized conditions

Colistin assay

HPLC

LC–MS/MS

LC–MS/MS

HPLC

VAP/VAT

VAT

VAP

VAP

VAP

Lung ELFmax (mg/L)

6.73 (4.8–10.1)

1137

NA

NA

Lung ELFmin (mg/L)

2.0 (1.0–3.8)

9.53

NA

NA

Plasma Cmax (mg/L)

1.6 (1.5–1.9)

0.73

2.9

2.2 ± 1.3

Plasma Cmin (mg/L)

0.3 (0.3–0.5)

0.15

2.4

1.4 ± 0.9

  1. Data are presented as mean ± SD, medians (25–75% interquartile) or maximum and minimum values
  2. HPLC High-performance liquid chromatography, VAP ventilator-associated pneumonia; VAT ventilator-associated tracheobronchitis, ELF epithelial lining fluid, LC–MS/MS liquid chromatography–tandem mass spectrometry, Cmax maximum plasma concentration, Cmin minimum plasma concentration
  3. a Blood sampled after the first dose; b blood sample performed at steady-state