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Table 2 Colistin ELF and plasma concentrations after nebulization with different doses

From: Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care

Study Athanassa [44] (n = 20)a Boisson [45] (n = 12)a Bihan [46] (n = 1)b Lu [6] (n = 16)b
Nebulized dose 1 MIU 2 MIU 4 MIU 5 MIU
Nebulizer Vibrating mesh nebulizer, continuous delivery, optimized conditions
Colistin assay HPLC LC–MS/MS LC–MS/MS HPLC
VAP/VAT VAT VAP VAP VAP
Lung ELFmax (mg/L) 6.73 (4.8–10.1) 1137 NA NA
Lung ELFmin (mg/L) 2.0 (1.0–3.8) 9.53 NA NA
Plasma Cmax (mg/L) 1.6 (1.5–1.9) 0.73 2.9 2.2 ± 1.3
Plasma Cmin (mg/L) 0.3 (0.3–0.5) 0.15 2.4 1.4 ± 0.9
  1. Data are presented as mean ± SD, medians (25–75% interquartile) or maximum and minimum values
  2. HPLC High-performance liquid chromatography, VAP ventilator-associated pneumonia; VAT ventilator-associated tracheobronchitis, ELF epithelial lining fluid, LC–MS/MS liquid chromatography–tandem mass spectrometry, Cmax maximum plasma concentration, Cmin minimum plasma concentration
  3. a Blood sampled after the first dose; b blood sample performed at steady-state