Table 1 Basic characteristics of ARDS patients (n = 78) on ECMO/pECLA with either argatroban or heparin
Argatroban (n = 39) | Heparin (n = 39) | p value | |
|---|---|---|---|
Basic characteristics | |||
Age (years) | 47 (36, 60) | 48 (35, 64) | 0.98 |
Sex (male) [n] | 27 (69.2%) | 27 (69.2%) | 0.99 |
Body mass index (kg/m2) | 27 (22.6, 28.7) | 26 (23.2, 28.9) | 0.80 |
Severity of illness scores at ICU admission | |||
SAPS II | 56 (40, 71) | 58 (40, 76) | 0.76 |
APACHE II | 31 (24, 38) | 28 (10.7, 38) | 0.28 |
SOFA | 13 (9, 14) | 12 (9, 15) | 0.97 |
TISS-28 | 48 (42, 56) | 50 (42, 58) | 0.53 |
Severity of ARDS | |||
Mild (n) | 9 (23.1%) | 4 (10.3%) | 0.22 |
Moderate (n) | 10 (25.6%) | 13 (33.3%) | 0.62 |
Severe (n) | 20 (51.3%) | 22 (56.4%) | 0.82 |
Lung injury score (points) | 3.25 (2.75, 3.5) | 3.3 (2.8, 3.8) | 0.51 |
Pulmonary gas exchange and mechanical ventilation | |||
PIP [cm H2O] | 36 (31, 39) | 35 (32, 37) | 0.58 |
PEEP [cm H2O] | 18 (15, 20) | 16 (14, 20) | 0.18 |
Delta P [cm H2O] | 19 (13, 24) | 18 (15, 21) | 0.84 |
FiO2 | 1, 0 (1, 0, 1, 0) | 1, 0 (0, 88, 1, 0) | 0.23 |
PaO2 [mmHg] | 91 (70, 155) | 77 (65, 117) | 0.26 |
PaO2/FiO2 | 97 (74, 166) | 92 (74, 124) | 0.40 |
Pulmonary compliance [ml/cmH2O] | 25 (15, 35) | 23 (17, 36) | 0.99 |
Etiology of ARDS | |||
Pneumonia (n) | 18 (46.2%) | 19 (48.7%) | 0.95 |
Sepsis (n) | 1 (2.6%) | 4 (10.3%) | 0.36 |
Immune deficiency (n) | 8 (20.5%) | 4 (10.3%) | 0.35 |
Acute on chronic (n) | 7 (17.9%) | 7 (17.9%) | 0.99 |
Trauma (n) | 4 (10.3%) | 0 (0%) | 0.12 |
Others (n) | 1 (2.6%) | 5 (12.8%) | 0.20 |
Extracorporeal lung support | |||
pECLA (n) | 9 (23.1%) | 15 (38.5%) | 0.20 |
ECMO (n) | 24 (61.5%) | 19 (48.7%) | 0.36 |
ECMO and pECLA (n) | 6 (15.4%) | 5 (12.8%) | 0.90 |
pECLA (h) | 164 (117, 258) | 220 (116, 393) | 0.59 |
ECMO (h) | 265 (131, 460) | 428 (180, 652) | 0.09 |
ICU mortality | 21 (54%) | 22 (56%) | 0.34 |