Table 2 Bleeding, thrombotic complications and replacements of extracorporeal lung support devices of ARDS patients on ECMO/pECLA with either argatroban or heparin
Argatroban | Heparin | p values | |||||
|---|---|---|---|---|---|---|---|
Patients (n) | Events. (n) | Event rate (mean) | Patients (n) | Events. (n) | Event rate (mean) | p (event rates) | |
Major bleedings: all | 11 | 14 | 2.7 (±5.3) | 13 | 33 | 3.8 (±6.8) | 0.57 |
Intracranial | 1 | 1 | 0.07 (±0.4) | 3 | 3 | 0.7 (±2.6) | 0.24 |
Pulmonary | 6 | 8 | 1.5 (±4.1) | 8 | 17 | 1.2 (±2.8) | 0.73 |
Gastrointestinal | 3 | 3 | 0.47 (±1.71) | 5 | 8 | 1.4 (±4.1) | 0.32 |
Other | 2 | 2 | 0.66 (±3.2) | 1 | 5 | 0.4 (±1.2) | 0.67 |
Minor bleedings: all | 30 | 91 | 19.3 (±19.4) | 31 | 126 | 22.1 (±23.7) | 0.58 |
Catheters. Gingival. Skin | 29 | 84 | 18.1 (±19.6) | 30 | 116 | 19.3 (±18.6) | 0.62 |
Wounds | 2 | 2 | 5.0 (±2.4) | 9 | 10 | 2.8 (±8.2) | 0.06 |
Other | 1 | 5 | 2.8 (17.3) | 0 | 0 | 0 (±0) | 1.00 |
Thrombotic complications: all | 6 | 11 | 2.5 (±9.9) | 3 | 4 | 0.8 (±2.5) | 0.54 |
Deep vein thrombosis | 1 | 1 | 0.38 (±2.3) | 0 | 0 | 0 (±0) | 1.00 |
Pulmonary embolism | 1 | 2 | 0.7 (±4.7) | 1 | 1 | 0.09 (±0.57) | 1.00 |
Cerebrovascular event | 1 | 1 | 0.3 (±1.6) | 1 | 1 | 0.2 (±1.3) | 1.00 |
Mesenteric infarction | 0 | 0 | 0 (±0) | 0 | 0 | 0 (±0) | – |
Myocardial infarction | 0 | 0 | 0 (±0) | 0 | 0 | 0 (±0) | – |
Peripheral artery closure | 1 | 1 | 0.4 (±2.3) | 0 | 0 | 0 (±0) | 1.00 |
Other | 4 | 6 | 0.8 (±3.3) | 2 | 2 | 0.5 (±2.2) | 0.61 |
Replacements | |||||||
pECLA cannula | 0 | 0 | 0 | 0 | 0 | 0 | – |
pECLA oxygenator | 8 | 29 | 12.9 (±10.1) | 10 | 23 | 5.4 (±7.5) | 0.17 |
ECMO cannula | 7 | 9 | 1.4 (±3.7) | 4 | 6 | 2.1 (±7.8) | 0.72 |
ECMO oxygenator | 15 | 36 | 8.5 (±14) | 11 | 21 | 5.5 (±7) | 0.88 |