Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases

Hilty, Matthias Peter; Franzen, Daniel Peter; Wyss, Christophe; Biaggi, Patric; Maggiorini, Marco

doi:10.1186/s13613-017-0307-0

Annals of Intensive Care

Table 2 Hemodynamic status and transpulmonary thermodilution measurements in patients with aortic valve stenosis, dilated cardiomyopathy, and controls

From: Validation of transpulmonary thermodilution variables in hemodynamically stable patients with heart diseases

	Control n = 11	AS n = 10	DCM n = 8	p
Heart rate [min⁻¹]	70 ± 9	67 ± 6	71 ± 13	0.62
Cardiac output (pulmonary artery catheter) [l min⁻¹]	5.0 ± 0.9	4.3 ± 1.4	4.0 ± 0.9	0.13
Left ventricular peak systolic pressure (sPlv) [mmHg]	145 ± 29	160 ± 34	126 ± 19	0.06
Mean aortic pressure (mPa) [mmHg]	103 ± 20	91 ± 14	90 ± 12	0.15
Left ventricular stroke work index (LVSWI) [g m s⁻² m⁻²]	82 ± 12	100 ± 28	63 ± 23^b	<0.01
Transaortic peak-to-peak pressure gradient (sPlv–sPa) [mmHg]	1 ± 8	19 ± 14^a	1 ± 4^b	<0.001
Right ventricular end-diastolic pressure (edPrv) [mmHg]	6 ± 4	6 ± 6	9 ± 6	0.27
Right atrial pressure (Pra) [mmHg]	4 ± 3	4 ± 2	7 ± 5	0.14
Mean pulmonary artery pressure (mPpa) [mmHg]	16 ± 6	16 ± 7	24 ± 11	0.08
Pulmonary artery occlusion pressure (Ppao) [mmHg]	8 ± 3	10 ± 5	14 ± 7^a	0.05
Transpulmonary pressure gradient (mPpa–Ppao) [mmHg]	8 ± 4	6 ± 3	9 ± 6	0.38
Pulmonary vascular resistance [dyn s cm⁻⁵]	108 ± 55	93 ± 50	173 ± 174	0.23
Biplanar left ventricular angiography
Stroke volume [ml]	64 ± 26	77 ± 20	76 ± 32	0.46
Left ventricular end-diastolic volume [ml]	104 ± 37	135 ± 63	234 ± 24^ab	<0.0001
Left ventricular ejection fraction [%]	62 ± 11	63 ± 16	32 ± 12^ab	<0.0001
Transpulmonary thermodilution (PiCCO2)
Cardiac output [l min⁻¹]	5.6 ± 0.9	5.5 ± 0.7	5.0 ± 1.0	0.35
Stroke volume [ml]	81 ± 15	84 ± 15	75 ± 25	0.57
Global end-diastolic volume index (GEDVI) [ml m⁻ ²]	823 ± 106	909 ± 170	870 ± 252	0.54
Global ejection fraction (GEF) [%]	22 ± 4	22 ± 4	20 ± 7	0.54
Cardiac function index (CFI) [min⁻¹]	3.9 ± 0.8	3.6 ± 0.7	3.3 ± 0.8	0.32
Extravascular lung water index (EVLWI) [ml kg⁻¹]	9 ± 2	12 ± 4^a	11 ± 3	0.04
Pulmonary vascular permeability index (PVPI) [1]	2 ± 0	2 ± 0	2 ± 1	0.12

Values are given as mean ± SD. Pairwise analysis is represented by^a,b where p < 0.05 versus the control and AS groups, respectively
AS aortic valve stenosis, DCM dilated cardiomyopathy

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