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Table 2 Opioid exposure and mechanical ventilation

From: Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study

Study group IWS-negative (n = 45)
Median (25th–75th percentile)
[min, max]
IWS-positive (n = 9)
Median (25th–75th percentile)
[min, max]
p value
Cumulative opioid dose prior to weaning (mcg/kg) 169.4 (117,7–234,2)
[11.7, 865.6]
245.7 (135,7–437,6)
[72.4, 722.4]
p = 0.32
Duration of opioid infusion until the first wean (h)a 125 (88–243)
[57, 564]
151 (81–397)
[76, 428]
p = 0.47
Duration of mechanical ventilation (h)b 188 (122–340)
[59, 1201]
286 (207–566)
[111, 1245]
p = 0.08
Weaning rate (%) 75 (50–100)
[12.50, 100]
100 (40–100)
[20, 100]
p = 0.98
  1. Weaning rate is defined as the difference between the previous stable infusion rate and the new stable infusion rate
  2. aThe last observation carried forward method was used for 1 patient in each group; opioid begin date = ICU admission date
  3. bThe last observation carried forward was used for 3 patients in IWS-negative group and 1 in IWS-positive group