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Annals of Intensive Care

Table 2 Opioid exposure and mechanical ventilation

From: Opioid-associated iatrogenic withdrawal in critically ill adult patients: a multicenter prospective observational study

Study group

IWS-negative (n = 45)

Median (25th–75th percentile)

[min, max]

IWS-positive (n = 9)

Median (25th–75th percentile)

[min, max]

p value

Cumulative opioid dose prior to weaning (mcg/kg)

169.4 (117,7–234,2)

[11.7, 865.6]

245.7 (135,7–437,6)

[72.4, 722.4]

p = 0.32

Duration of opioid infusion until the first wean (h)a

125 (88–243)

[57, 564]

151 (81–397)

[76, 428]

p = 0.47

Duration of mechanical ventilation (h)b

188 (122–340)

[59, 1201]

286 (207–566)

[111, 1245]

p = 0.08

Weaning rate (%)

75 (50–100)

[12.50, 100]

100 (40–100)

[20, 100]

p = 0.98

  1. Weaning rate is defined as the difference between the previous stable infusion rate and the new stable infusion rate
  2. aThe last observation carried forward method was used for 1 patient in each group; opioid begin date = ICU admission date
  3. bThe last observation carried forward was used for 3 patients in IWS-negative group and 1 in IWS-positive group
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