TY - JOUR AU - Lehner, Georg Franz AU - Harler, Ulrich AU - Feistritzer, Clemens AU - Haller, Viktoria Maria AU - Hasslacher, Julia AU - Bellmann, Romuald AU - Joannidis, Michael PY - 2017 DA - 2017/09/04 TI - Hemofiltration induces generation of leukocyte-derived CD31+/CD41− microvesicles in sepsis JO - Annals of Intensive Care SP - 89 VL - 7 IS - 1 AB - Microvesicles (MV) are extracellular vesicles known to be associated with cellular activation and inflammation. Hemofiltration is an effective blood purification technique for patients with renal failure and possibly also eliminates inflammatory mediators in the setting of sepsis. On the other hand, proinflammatory stimuli are induced by blood contacting the artificial membrane during extracorporeal blood purification. In chronic dialysis patients a systemic increase in MV has been described. The aim of the study was to investigate whether hemofilter passage of blood in continuous veno-venous hemofiltration (CVVH) alters MV composition and levels in critically ill patients with sepsis. SN - 2110-5820 UR - https://doi.org/10.1186/s13613-017-0312-3 DO - 10.1186/s13613-017-0312-3 ID - Lehner2017 ER -