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Table 1 Plasma pharmacokinetic parameters of AS in sham and CS rats

From: Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

  AUC0–∞h (μg h/mL) MRT (h) CLtot (mL/h) V ss (mL) K el (h−1) T 1/2 (h) T max (h) C max (μg/mL)
Sham-AS 32.9 ± 1.5 2.1 ± 0.0 84.4 ± 4.2 219 ± 41 0.80 ± 0.03 0.88 ± 0.04 1.83 ± 0.33 10.1 ± 0.4
C-AS 36.0 ± 1.3* 2.6 ± 0.2* 78.6 ± 3.4 244 ± 28 0.49 ± 0.02* 1.37 ± 0.03* 2.70 ± 0.11 * 10.3 ± 0.3
  1. Values are presented as the mean ± SEM (n = 3–6)
  2. AUC area under the concentration–time curve, MRT mean residence time, CL tot total body clearance, V ss steady-state volume of distribution, K el elimination rate constant, T 1/2 biological half-life, T max time to maximum drug concentration, C max maximum drug concentration, AS astragaloside-IV, CS crush syndrome
  3. *p < 0.05 versus sham-AS group analyzed by Student’s t test