Skip to main content
Annals of Intensive Care

Table 1 Plasma pharmacokinetic parameters of AS in sham and CS rats

From: Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

 

AUC0–∞h (μg h/mL)

MRT (h)

CLtot (mL/h)

V ss (mL)

K el (h−1)

T 1/2 (h)

T max (h)

C max (μg/mL)

Sham-AS

32.9 ± 1.5

2.1 ± 0.0

84.4 ± 4.2

219 ± 41

0.80 ± 0.03

0.88 ± 0.04

1.83 ± 0.33

10.1 ± 0.4

C-AS

36.0 ± 1.3*

2.6 ± 0.2*

78.6 ± 3.4

244 ± 28

0.49 ± 0.02*

1.37 ± 0.03*

2.70 ± 0.11 *

10.3 ± 0.3

  1. Values are presented as the mean ± SEM (n = 3–6)
  2. AUC area under the concentration–time curve, MRT mean residence time, CL tot total body clearance, V ss steady-state volume of distribution, K el elimination rate constant, T 1/2 biological half-life, T max time to maximum drug concentration, C max maximum drug concentration, AS astragaloside-IV, CS crush syndrome
  3. *p < 0.05 versus sham-AS group analyzed by Student’s t test
Back to article page