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Table 2 Patients’ baseline characteristics for the derivation, geographic and temporal external validation sub-cohorts

From: Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis

Cohort Derivation (UK until Jan 2011) Geographic validation (non-UK) Temporal validation (UK post-Jan 2011)
Total number of patients 462 515 323
Characteristics Median or n IQR or % Median or n IQR or % Median or n IQR or %
Age
Available data 462 100% 515 100% 323 100%
 18–34 11 2.4% 25 4.9% 11 3.4%
 35–44 15 3.3% 18 3.5% 16 5%
 45–54 54 11.7% 52 10.1% 38 11.8%
 55–64 93 20.1% 98 19% 73 22.6%
 65–74 113 24.5% 151 29.3% 88 27.2%
 75–84 149 32.3% 149 28.9% 75 23.2%
 85–95 27 5.8% 22 4.3% 22 6.8%
Gender
Available data 462 100% 515 100% 323 100%
 Male 236 51.1% 304 59% 171 52.9%
 Female 226 48.9% 211 41% 152 47.1%
Race
Available data 460 99.6% 510 99% 323 100%
 Caucasian 454 98.7% 502 98.4% 315 97.5%
 Asian 4 0.9% 7 1.4% 3 0.9%
 African 1 0.2% 1 0.2% 3 0.9%
 Mixed 1 0.2% 0 0% 2 0.6%
Medical comorbidities
Available data 462 100% 515 100% 323 100%
 Heart and vascular disease 187 40.6% 202 39.2% 117 36.2%
 Respiratory disease 111 24.1% 133 25.8% 97 30%
 Neurological disease 48 10.4% 57 11.1% 24 7.4%
 Severe renal disease 39 8.6% 21 4.3% 16 5%
 Gastrointestinal disease 98 21.3% 132 25.7% 76 23.5%
 Malignancy 135 29.3% 160 31.1% 84 26%
 Diabetes 61 13.2% 102 19.8% 44 13.6%
 Previous serious infectiona 8 1.7% 25 4.9% 5 1.6%
 Other illness 130 28.2% 210 40.8% 83 25.7%
 Severe exercise restriction 3 0.7% 6 1.2% 1 0.3%
 Chronic dialysis 5 1.1% 8 1.6% 5 1.6%
 Chronic steroids useb 2 0.4% 9 1.8% 5 1.6%
Cause of FP
Available data 461 99.8% 511 99.2% 323 100%
 Perforated diverticulum 137 29.7% 175 34.3% 89 27.6%
 Anastomotic breakdown 115 25% 187 36.6% 61 18.9%
 Malignancy 65 14.1% 64 12.5% 35 10.8%
 Trauma 22 4.8% 45 8.8% 16 5%
 Other 122 26.5% 40 7.8% 124 38.4%
Time to surgery (days) 1 1–3 1 1–3 1 1–3
Acute physiology
Available data 461 99.8% 513 99.6% 321 99.4%
 APACHE II score 15 12–20 17 13–22 16 12–21
 SOFA score 7 5–9 7 5–11 6 5–8
 Acute renal failure 129 32.7% 214 42.8% 70 21.8%
 Renal replacement therapy 81 21% 105 21.3% 26 8.1%
 Mechanical ventilation 346 75.1% 397 77.4% 228 71%
  1. APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment
  2. aSerious infection was defined as a serious, prolonged or recurrent infection
  3. bChronic steroid use was defined as taking corticosteroids below the immunosuppression dose (>7 mg/kg/days hydrocortisone), which would exclude patient from inclusion in the study