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Table 7 Summaries of performance statistics of presepsin, procalcitonin, and C-reactive protein for diagnosing sepsis

From: Comparison of diagnostic accuracy in sepsis between presepsin, procalcitonin, and C-reactive protein: a systematic review and meta-analysis

Category Biomarkers Number of studies Number of patients Pooled sensitivity Pooled specificity AUC Pooled DOR
All Presepsin 13 2915 0.84 (0.79–0.88) 0.75 (0.64–0.84) 0.87 (0.84–0.90) 16 (8–30)
Procalcitonin 13 2915 0.78 (0.72–0.83) 0.79 (0.73–0.85) 0.86 (0.82–0.88) 14 (8–23)
All Presepsin 7 1204 0.83 (0.76–0.88) 0.70 (0.55–0.81) 0.85 (0.81–0.88) 11 (7–18)
C-reactive protein 7 1204 0.77 (0.53–0.91) 0.79 (0.62–0.89) 0.85 (0.82–0.88) 13 (5–36)
ED Presepsin 6 1822 0.83 (0.68–0.92) 0.83 (0.67–0.92) 0.90 (0.87–0.92) 24 (5–113)
Procalcitonin 6 1822 0.79 (0.68–0.87) 0.83 (0.72–0.91) 0.88 (0.85–0.90) 19 (7–52)
ICU Presepsin 5 452 0.88 (0.82–0.92) 0.58 (0.42–0.73) 0.87 (0.84–0.90) 10 (5–18)
Procalcitonin 5 452 0.75 (0.68–0.81) 0.75 (0.65–0.83) 0.82 (0.78–0.85) 9 (6–15)
Sepsis-1/2 Presepsin 7 2076 0.86 (0.76–0.91) 0.79 (0.60–0.91) 0.90 (0.87–0.92) 23 (7–77)
Procalcitonin 7 2076 0.80 (0.72–0.87) 0.83 (0.75–0.89) 0.89 (0.86–0.91) 20 (9–45)
Sepsis-1/2 Presepsin 3 694 0.86 (0.75–0.93) 0.69 (0.33–0.90) 0.87 (0.83–0.91) 16 (6–38)
C-reactive protein 3 694 0.86 (0.44–0.98) 0.85 (0.63–0.95) 0.91 (0.86–0.93) 34 (9–127)