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Table 1 Main characteristics of the study population in subgroups of AKI/non-AKI and septic/non-septic patients

From: Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

 

Total

Non-AKI

AKI

p value

Non-septic

Septic

p value

n

98

49

49

58

40

Men

65 (66.3%)

30 (61.2%)

35 (71.4%)

NS

38 (65.5%)

27 (67.5%)

NS

Age (years)

55 ± 17.3

50.4 ± 17.9

59.9 ± 15.5

0.006

50.9 ± 16.6

61.2 ± 16.8

0.003

Renal characteristics

 Baseline eGFR (mL/min) n = 86

110.6 ± 53.7

120.5 ± 60.5

100.7 ± 44.6

NS

121.9 ± 58.9

94.8 ± 41.2

0.020

 Baseline creatinine (μmol/L) n = 86

79 ± 31.5

80.5 ± 32.3

78.1 ± 31.1

NS

79.6 ± 28.9

78.9 ± 35.1

NS

 Creatinine upon ICU admission

94.1 ± 42.2

74.6 ± 30.2

113.1 ± 43.9

<0.001

85.0 ± 36.8

106.9 ± 46.5

0.015

 AKI at admission

44 (44.9%)

44 (89.8%)

20 (34.5%)

24 (60%)

0.013

 AKIN ≥ 2 upon ICU admission

25 (25.5%)

25 (51%)

9 (15.5%)

16 (40%)

0.009

 Renal replacement <48 h

5 (5.1%)

0 (0%)

5 (10.2%)

0.056

4 (6.9%)

1 (2.5%)

NS

 Worst value [TIMP-2]·[IGFBP7] ((ng/mL)2/1000)

0.41 (0.20–1.36)

0.24 (0.11–0.48)

1.03 (0.38–3.29)

<0.001

0.36 (0.14–1.08)

0.56 (0.26–2.94)

NS

ICU epidemiological data

 Shock

35 (35.7%)

11 (22.5%)

24 (50%)

0.011

10 (17.2%)

25 (62.5%)

<0.001

 Septic shock

19 (19.4%)

6 (12.3%)

13 (26.5%)

NS

19 (47.5%)

 Mechanical ventilation

79 (80.6%)

39 (79.6%)

40 (81.6%)

NS

44 (75.9%)

35 (87.5%)

NS

 SAPS II

37.4 ± 18.3

30.9 ± 14.9

43.9 ± 19.2

<0.001

30.9 ± 15.6

46.8 ± 18.1

<0.001

 APACHE II

15.7 ± 8.2

13.5 ± 7.7

17.9 ± 8.2

0.007

14.2 ± 8.5

17.9 ± 7.3

0.024

 SOFA at ICU admission

7.5 ± 3.7

6.1 ± 3.2

8.9 ± 3.7

<0.001

6.7 ± 3.7

8.7 ± 3.4

0.009

 ICU LOS (days)

11.1 ± 14.6

10.0 ± 10.6

12.3 ± 18.8

NS

9.3 ± 11.0

13.9 ± 18.5

NS

 Hospital LOS (days)

23.6 ± 25.0

23.4 ± 23.3

23.8 ± 27.0

NS

21.4 ± 21.3

26.9 ± 29.6

NS

 ICU mortality

10 (10.2%)

4 (8.2%)

6 (12.3%)

NS

6 (10.3%)

4 (10%)

NS

  1. Values expressed as either % per column, mean ± standard deviation or median and interquartile range. p value of statistical significance
  2. NS no statistical significance, AKI acute kidney injury, AKIN acute kidney injury network definition, APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit, LOS length of stay, SAPS II Simplified Acute Physiology Score II, SOFA sequential organ failure assessment score