Skip to main content

Table 1 Main characteristics of the study population in subgroups of AKI/non-AKI and septic/non-septic patients

From: Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

  Total Non-AKI AKI p value Non-septic Septic p value
n 98 49 49 58 40
Men 65 (66.3%) 30 (61.2%) 35 (71.4%) NS 38 (65.5%) 27 (67.5%) NS
Age (years) 55 ± 17.3 50.4 ± 17.9 59.9 ± 15.5 0.006 50.9 ± 16.6 61.2 ± 16.8 0.003
Renal characteristics
 Baseline eGFR (mL/min) n = 86 110.6 ± 53.7 120.5 ± 60.5 100.7 ± 44.6 NS 121.9 ± 58.9 94.8 ± 41.2 0.020
 Baseline creatinine (μmol/L) n = 86 79 ± 31.5 80.5 ± 32.3 78.1 ± 31.1 NS 79.6 ± 28.9 78.9 ± 35.1 NS
 Creatinine upon ICU admission 94.1 ± 42.2 74.6 ± 30.2 113.1 ± 43.9 <0.001 85.0 ± 36.8 106.9 ± 46.5 0.015
 AKI at admission 44 (44.9%) 44 (89.8%) 20 (34.5%) 24 (60%) 0.013
 AKIN ≥ 2 upon ICU admission 25 (25.5%) 25 (51%) 9 (15.5%) 16 (40%) 0.009
 Renal replacement <48 h 5 (5.1%) 0 (0%) 5 (10.2%) 0.056 4 (6.9%) 1 (2.5%) NS
 Worst value [TIMP-2]·[IGFBP7] ((ng/mL)2/1000) 0.41 (0.20–1.36) 0.24 (0.11–0.48) 1.03 (0.38–3.29) <0.001 0.36 (0.14–1.08) 0.56 (0.26–2.94) NS
ICU epidemiological data
 Shock 35 (35.7%) 11 (22.5%) 24 (50%) 0.011 10 (17.2%) 25 (62.5%) <0.001
 Septic shock 19 (19.4%) 6 (12.3%) 13 (26.5%) NS 19 (47.5%)
 Mechanical ventilation 79 (80.6%) 39 (79.6%) 40 (81.6%) NS 44 (75.9%) 35 (87.5%) NS
 SAPS II 37.4 ± 18.3 30.9 ± 14.9 43.9 ± 19.2 <0.001 30.9 ± 15.6 46.8 ± 18.1 <0.001
 APACHE II 15.7 ± 8.2 13.5 ± 7.7 17.9 ± 8.2 0.007 14.2 ± 8.5 17.9 ± 7.3 0.024
 SOFA at ICU admission 7.5 ± 3.7 6.1 ± 3.2 8.9 ± 3.7 <0.001 6.7 ± 3.7 8.7 ± 3.4 0.009
 ICU LOS (days) 11.1 ± 14.6 10.0 ± 10.6 12.3 ± 18.8 NS 9.3 ± 11.0 13.9 ± 18.5 NS
 Hospital LOS (days) 23.6 ± 25.0 23.4 ± 23.3 23.8 ± 27.0 NS 21.4 ± 21.3 26.9 ± 29.6 NS
 ICU mortality 10 (10.2%) 4 (8.2%) 6 (12.3%) NS 6 (10.3%) 4 (10%) NS
  1. Values expressed as either % per column, mean ± standard deviation or median and interquartile range. p value of statistical significance
  2. NS no statistical significance, AKI acute kidney injury, AKIN acute kidney injury network definition, APACHE II acute physiology and chronic health evaluation II, ICU intensive care unit, LOS length of stay, SAPS II Simplified Acute Physiology Score II, SOFA sequential organ failure assessment score