From: Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS?
PT | Autoantibodies | BAL | CT findings at presentation | ILD pattern at CT | CT findings at follow-up |
---|---|---|---|---|---|
PT 1 | ANA; SSA/Ro52; anti-centromere | Lymphocytic cellular pattern (MA 42%; L 35%; PMN 14%; E 2%) | Extensive GGO with crazy-paving mainly in dependent zones and with subpleural sparing; consolidations in costophrenic sulci; some cystic lesions mainly in lower areas | LIP | Minimal diffuse GGO and subpleural reticulations; rare traction bronchiolectasis; enlarged cystic lesions (20 months) |
PT 2 | SSA/Ro52 | Neutrophilic cellular pattern (MA 9%; L 0%; PMN 91%; E 0%); Foam cells +++ | Focal subpleural and peribroncovascular consolidations in upper lobes and extensive consolidations of RLL, with air bronchogram | OP | Extensive parenchymal fibrosis with large bilateral pleural effusions (after 2 months of ICU stay) |
PT3 | SSA/Ro52 | Physiological cellular pattern (MA 93%; L 2%; PMN 5%, E 0%); Foam cells +++ | Subpleural consolidations with air bronchogram, mainly in lower lobes, with perilobular consolidations in RUL | OP | Diffuse reticulations with architectural distortion and subpleural curvilinear lines; limited traction bronchiectasis (17 months) |
PT 4 | ANA; SSA/Ro52 | Neutrophilic cellular pattern (MA 9%; L 9%; PMN 83%; E 5%) | Limited gravity-dependent consolidations with air bronchogram and GGO; some areas of perilobular consolidations | OP | Gradual development of extensive GGO with reticulations, mainly in lower lobes with traction bronchiectasis (24 months) |
PT 5 | Anti-Jo1; SSA/Ro52 | Lymphocytic cellular pattern (MA 27%; L 57%; PMN 14%; E 2%) | Diffuse GGO with subpleural sparing and crazy paving; subpleural consolidations mainly dorsal; initial signs of fibrosis with corkscrew-like traction bronchiectasis in RUL consolidated areas | AIP/DAD | Minimal subpleural GGO with reticulations; traction bronchiolectasis in RUL (23 months) |
PT 6 | ANA; SSA/Ro52 | Lymphocytic cellular pattern (MA 60%; L 30%; PMN 10%; E 0%) | Bilateral consolidations with air bronchogram in lower lobes and dorsal segments of upper lobes. Some GGO in lower lobes and anterior segments of upper lobes. Limited reticulations anteriorly | OP | NA |
PT 7 | ANA (nucleolar pattern) | Physiological cellular pattern (MA 95%; L 1%; PMN 3%, E 1%) | Bilateral quite extensive GGO in upper and lower lobes, with subpleural and peribronchovascular distribution, associated with minimal reticulations in upper lobes and limited consolidations in lower lobes | OP/NSIP overlap | NA |